The Baylis-Hillman Adducts as Valuable Source for One-Pot Multi-Step Synthesis: A Facile Synthesis of Substituted Piperidin-2-ones

A facile, convenient, and one‐pot multi‐step synthesis of substituted piperidin‐2‐ones from the Baylis–Hillman alcohols derived from various aldehydes and acrylonitrile, involving Johnson–Claisen rearrangement, reduction of an α,β‐unsaturated nitrile moiety into the saturated amine‐skeleton, followe...

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Bibliographic Details
Published in:Helvetica chimica acta 2010-06, Vol.93 (6), p.1180-1186
Main Authors: Basavaiah, Deevi, Reddy, Raju Jannapu, Lenin, Dandamudi V.
Format: Article
Language:English
Subjects:
Baylis-Hillman adducts
Johnson-Claisen rearrangement
Multicomponent reactions
Piperidin-2-ones
X-Ray crystallography
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Summary:A facile, convenient, and one‐pot multi‐step synthesis of substituted piperidin‐2‐ones from the Baylis–Hillman alcohols derived from various aldehydes and acrylonitrile, involving Johnson–Claisen rearrangement, reduction of an α,β‐unsaturated nitrile moiety into the saturated amine‐skeleton, followed by cyclization, in an operationally simple procedure, is described.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.200900352