Polyoxygenated Sterols from Freshwater Clam

Two new biologically active polyoxygenated sterols, 3,5,9‐trihydroxycholest‐7‐en‐6‐one (1) and cholest‐7‐ene‐3,6,9‐triol (3), together with one known sterone, topsentisterol D3 (2), were isolated from freshwater clam (Corbicula fluminea Muller; an important cultured edible shellfish in Taiwan). The...

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Bibliographic Details
Published in:Helvetica chimica acta 2011-05, Vol.94 (5), p.892-896
Main Authors: Kong, Zwe-Ling, Chi Yu, Siauo, Ai Dai, Shu, Tu, Cha-Chung, Pan, Min-Hsiung, Liu, Yeuk-Chuen
Format: Article
Language:English
Subjects:
Corbicula fluminea
Cytotoxic activity
Freshwater clam
Sterols
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Summary:Two new biologically active polyoxygenated sterols, 3,5,9‐trihydroxycholest‐7‐en‐6‐one (1) and cholest‐7‐ene‐3,6,9‐triol (3), together with one known sterone, topsentisterol D3 (2), were isolated from freshwater clam (Corbicula fluminea Muller; an important cultured edible shellfish in Taiwan). The structure elucidation of sterols 1–3 were accomplished by 1H‐ and 13C‐NMR, HMQC, and HMBC, and MS analyses. The sterols 1–3 displayed cytotoxicities against the human hepatoma Hep G2 cells (IC50: 6.04±0.07, 40.78±4.28, and 10.57±0.51 μg/ml, resp.).
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201000405