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Polyoxygenated Sterols from Freshwater Clam
Two new biologically active polyoxygenated sterols, 3,5,9‐trihydroxycholest‐7‐en‐6‐one (1) and cholest‐7‐ene‐3,6,9‐triol (3), together with one known sterone, topsentisterol D3 (2), were isolated from freshwater clam (Corbicula fluminea Muller; an important cultured edible shellfish in Taiwan). The...
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Published in: | Helvetica chimica acta 2011-05, Vol.94 (5), p.892-896 |
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creator | Kong, Zwe-Ling Chi Yu, Siauo Ai Dai, Shu Tu, Cha-Chung Pan, Min-Hsiung Liu, Yeuk-Chuen |
description | Two new biologically active polyoxygenated sterols, 3,5,9‐trihydroxycholest‐7‐en‐6‐one (1) and cholest‐7‐ene‐3,6,9‐triol (3), together with one known sterone, topsentisterol D3 (2), were isolated from freshwater clam (Corbicula fluminea Muller; an important cultured edible shellfish in Taiwan). The structure elucidation of sterols 1–3 were accomplished by 1H‐ and 13C‐NMR, HMQC, and HMBC, and MS analyses. The sterols 1–3 displayed cytotoxicities against the human hepatoma Hep G2 cells (IC50: 6.04±0.07, 40.78±4.28, and 10.57±0.51 μg/ml, resp.). |
doi_str_mv | 10.1002/hlca.201000405 |
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The structure elucidation of sterols 1–3 were accomplished by 1H‐ and 13C‐NMR, HMQC, and HMBC, and MS analyses. The sterols 1–3 displayed cytotoxicities against the human hepatoma Hep G2 cells (IC50: 6.04±0.07, 40.78±4.28, and 10.57±0.51 μg/ml, resp.).</description><identifier>ISSN: 0018-019X</identifier><identifier>EISSN: 1522-2675</identifier><identifier>DOI: 10.1002/hlca.201000405</identifier><language>eng</language><publisher>Zürich: WILEY-VCH Verlag</publisher><subject>Corbicula fluminea ; Cytotoxic activity ; Freshwater clam ; Sterols</subject><ispartof>Helvetica chimica acta, 2011-05, Vol.94 (5), p.892-896</ispartof><rights>Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich, Switzerland</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3275-c8ef5aa16f048387c7b8fd33f29f25d8023b9202d237a06d84d19dfd19cf69db3</citedby><cites>FETCH-LOGICAL-c3275-c8ef5aa16f048387c7b8fd33f29f25d8023b9202d237a06d84d19dfd19cf69db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Kong, Zwe-Ling</creatorcontrib><creatorcontrib>Chi Yu, Siauo</creatorcontrib><creatorcontrib>Ai Dai, Shu</creatorcontrib><creatorcontrib>Tu, Cha-Chung</creatorcontrib><creatorcontrib>Pan, Min-Hsiung</creatorcontrib><creatorcontrib>Liu, Yeuk-Chuen</creatorcontrib><title>Polyoxygenated Sterols from Freshwater Clam</title><title>Helvetica chimica acta</title><addtitle>HCA</addtitle><description>Two new biologically active polyoxygenated sterols, 3,5,9‐trihydroxycholest‐7‐en‐6‐one (1) and cholest‐7‐ene‐3,6,9‐triol (3), together with one known sterone, topsentisterol D3 (2), were isolated from freshwater clam (Corbicula fluminea Muller; an important cultured edible shellfish in Taiwan). The structure elucidation of sterols 1–3 were accomplished by 1H‐ and 13C‐NMR, HMQC, and HMBC, and MS analyses. 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The structure elucidation of sterols 1–3 were accomplished by 1H‐ and 13C‐NMR, HMQC, and HMBC, and MS analyses. The sterols 1–3 displayed cytotoxicities against the human hepatoma Hep G2 cells (IC50: 6.04±0.07, 40.78±4.28, and 10.57±0.51 μg/ml, resp.).</abstract><cop>Zürich</cop><pub>WILEY-VCH Verlag</pub><doi>10.1002/hlca.201000405</doi><tpages>5</tpages></addata></record> |
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subjects | Corbicula fluminea Cytotoxic activity Freshwater clam Sterols |
title | Polyoxygenated Sterols from Freshwater Clam |
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