Alkaloid and Anthraquinone Derivatives Produced by the Marine-Derived Endophytic Fungus Eurotium rubrum

Cultivation of the fungal strain Eurotium rubrum, an endophytic fungus that was isolated from the inner tissue of the semi‐mangrove plant Hibiscus tiliaceus, resulted in the isolation of one new dioxopiperazine alkaloid, 12‐demethyl‐12‐oxo‐eurotechinulin B (1), and one new anthraquinone derivative,...

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Bibliographic Details
Published in:Helvetica chimica acta 2012-01, Vol.95 (1), p.163-168
Main Authors: Yan, Hui-Jiao, Li, Xiao-Ming, Li, Chun-Shun, Wang, Bin-Gui
Format: Article
Language:English
Subjects:
12-demethyl-12-oxo
9-Dehydroxyeurotinone
Antibacterial activity
Antifungal activity
Cytotoxic activity
Eurotechinulin B
Eurotechinulin B, 12‐demethyl‐12‐oxo
Eurotium rubrum
Hibiscus tiliaceus
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Summary:Cultivation of the fungal strain Eurotium rubrum, an endophytic fungus that was isolated from the inner tissue of the semi‐mangrove plant Hibiscus tiliaceus, resulted in the isolation of one new dioxopiperazine alkaloid, 12‐demethyl‐12‐oxo‐eurotechinulin B (1), and one new anthraquinone derivative, 9‐dehydroxyeurotinone (2), together with ten known compounds including variecolorin J (3), eurotechinulin B (4), variecolorin G (5), alkaloid E‐7 (6), cryptoechinuline G (7), isoechinulin B (8), 7‐isopentenylcryptoechinuline D (9), 2‐O‐methyl‐9‐dehydroxyeurotinone (10), emodin (11), and emodic acid (12). The structures of the isolated compounds were determined by extensive analysis of their spectroscopic data as well as by comparison with literature reports. Some of the purified compounds were evaluated for antibacterial, antifungal, and cytotoxic activities.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201100255