Preparation of Isotope Labeled/Unlabeled Key Intermediates in 2-Methyl-D-erythritol 4-Phosphate Terpenoid Biosynthetic Pathway

Naturally occurring terpenes constitute one of the largest groups of natural products with complicated and variable structures, and a great number of important biological activities. The 2‐methyl‐D‐erythritol 4‐phosphate (MEP) pathway is a newly found and established biosynthetic route for terpenoid...

Full description

Saved in:
Bibliographic Details
Published in:Helvetica chimica acta 2012-05, Vol.95 (5), p.683-715
Main Authors: Li, Heng, Dai, Shao-Bo, Gao, Wen-Yun
Format: Article
Language:English
Subjects:
2-Methyl-D-erythritol 4-phosphate (MEP)
Biosynthesis
Isotope labeling
MEP Pathway
Terpenoids
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Naturally occurring terpenes constitute one of the largest groups of natural products with complicated and variable structures, and a great number of important biological activities. The 2‐methyl‐D‐erythritol 4‐phosphate (MEP) pathway is a newly found and established biosynthetic route for terpenoids, and all the enzymes involved in this pathway can be used as targets for the screening of antibiotics. Progress in chemical and enzymatic preparation of the key intermediates in this pathway is reviewed with the emphasis on the synthesis of 1‐deoxy‐D‐xylulose 5‐phosphate and 2‐methyl‐D‐erythritol 4‐phosphate with isotope labels.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201100396