Orally disintegrating olanzapine and potential differences in treatment-emergent weight gain

Several papers and communications have reported possible weight reduction or less weight gain when patients start or switch to orally disintegrating olanzapine, as contrasted with standard oral olanzapine tablets. In this paper, the current literature is reviewed and hypothesized mechanisms of actio...

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Bibliographic Details
Published in:Human psychopharmacology 2008-06, Vol.23 (4), p.275-281
Main Authors: Karagianis, Jamie, Hoffmann, Vicki Poole, Arranz, Belen, Treuer, Tamás, Maguire, Gerald A., de Haan, Lieuwe, Chawla, Bharat
Format: Article
Language:English
Subjects:
Administration, Oral
Antipsychotic Agents - administration & dosage
Antipsychotic Agents - adverse effects
Antipsychotic Agents - therapeutic use
atypical antipsychotic
Benzodiazepines - administration & dosage
Benzodiazepines - adverse effects
Benzodiazepines - therapeutic use
disintegrating
dissolving
Drug Delivery Systems
Humans
olanzapine
Patient Compliance
Schizophrenia - drug therapy
Solubility
Tablets
weight
Weight Gain - drug effects
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Summary:Several papers and communications have reported possible weight reduction or less weight gain when patients start or switch to orally disintegrating olanzapine, as contrasted with standard oral olanzapine tablets. In this paper, the current literature is reviewed and hypothesized mechanisms of action are discussed. The data are still preliminary and mechanisms of action are not well understood. Randomized controlled trials are needed to further evaluate change in weight during treatment with orally disintegrating olanzapine. Copyright © 2008 John Wiley & Sons, Ltd.
ISSN:0885-6222
1099-1077
DOI:10.1002/hup.933