International trends and patterns of primary liver cancer

Primary liver cancer (PLC) is common in many areas of the developing world, but uncommon in most of the developed world. Some evidence suggests, however, that the global pattern of PLC may be changing. To clarify this issue, we examined incidence rates for PLC over the 15‐year time period, 1978–92,...

Full description

Saved in:
Bibliographic Details
Published in:International journal of cancer 2001-10, Vol.94 (2), p.290-296
Main Authors: McGlynn, Katherine A., Tsao, Lilian, Hsing, Ann W., Devesa, Susan S., Fraumeni, Joseph F.
Format: Article
Language:English
Subjects:
aflatoxin B1
Aflatoxin B1 - adverse effects
Biological and medical sciences
Carcinoma, Hepatocellular - epidemiology
Cholangiocarcinoma - epidemiology
Female
Gastroenterology. Liver. Pancreas. Abdomen
hepatitis B
hepatitis C
Hepatitis C, Chronic - complications
hepatocellular carcinoma
Humans
Incidence
Liver Neoplasms - epidemiology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Registries
Time Factors
Tropical medicine
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Primary liver cancer (PLC) is common in many areas of the developing world, but uncommon in most of the developed world. Some evidence suggests, however, that the global pattern of PLC may be changing. To clarify this issue, we examined incidence rates for PLC over the 15‐year time period, 1978–92, in selected cancer registries around the world. With some exceptions, developed countries have experienced PLC increases in incidence whereas developing countries have experienced declines. Although the reasons for the trends are not entirely clear, the increased seroprevalence of HCV in the developed world and the elimination of HBV‐cofactors in the developing world are likely to have contributed to the patterns. Further progress against PLC may be seen in the developing world once the HBV‐vaccinated segment of the population reaches adulthood. Published 2001 Wiley‐Liss, Inc.
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.1456