Antioxidant protection by β‐selenoamines against thioacetamide‐induced oxidative stress and hepatotoxicity in mice

• Published in: Journal of biochemical and molecular toxicology 2017-12, Vol.31 (12), p.n/a
• Main Authors: Stefanello, Sílvio Terra, Hartmann, Diane Duarte, Amaral, Guilherme Pires, Courtes, Aline Alves, Leite, Martim T. B., da Silva, Thayanara Cruz, Gonçalves, Débora Farina, Souza, Micaela B., da Rosa, Pâmela Carvalho, Dornelles, Luciano, Soares, Félix Alexandre Antunes
• Format: Article
• Language: English
• Subjects: Amines - pharmacology; Animals; Antioxidants - pharmacology; Chemical and Drug Induced Liver Injury - metabolism; Chemical and Drug Induced Liver Injury - prevention & control; Drug Evaluation, Preclinical; Glutathione - metabolism; Glutathione Peroxidase - metabolism; Glutathione Transferase - metabolism; Lipid Peroxidation; Liver - drug effects; Liver - enzymology; Liver - pathology; liver damage; Male; Mice; organic selenium compounds; Organoselenium Compounds - pharmacology; oxidative stress; Oxidative Stress - drug effects; Reactive Oxygen Species - metabolism; selenol; Thioacetamide
• ISSN: 1095-6670; 1099-0461
• DOI: 10.1002/jbt.21974

Thioacetamide (TAA) is a hepatotoxin that rapidly triggers the necrotic process and oxidative stress in the liver. Nevertheless, organic selenium compounds, such as β‐selenoamines, can be used as pharmacological agents to diminish the oxidative damage. Thus, the aim of this study was to investigate the protective effect of the antioxidant β‐selenoamines on TAA‐induced oxidative stress in mice. Here, we observed that a single intraperitoneal injection of TAA (200 mg/kg) dramatically elevated some parameters of oxidative stress, such as lipid peroxidation and reactive oxygen species (ROS) production, as well as depleted cellular antioxidant defenses. In addition, TAA‐induced edema and morphological changes in the liver, which correlate with high serum aspartate and alanine aminotransferase enzyme activities, and a decrease in cell viability. Conversely, a significant reduction in liver lipid peroxidation, ROS production, and edema was observed in animals that received an intraperitoneal injection of β‐selenoamines (15.6 mg/kg) 1 h after TAA administration.