Spectrophotometric Determination of Some Fluoroquinolone Antibacterials by Ion-pair Complex Formation with Cobalt (II) Tetrathiocyanate

A new simple extractive spectrophotometric method has been developed for the determination of levofloxacin (I), norfloxacin (II), and ciprofloxacin (III) in pure form and tablets. The method is based on the formation of blue‐colored ion‐pair associates between the drugs and the inorganic complex, co...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the Chinese Chemical Society (Taipei) 2005-02, Vol.52 (1), p.77-84
Main Authors: El-Brashy, Amina Mohamed, Metwally, Mohamed El-Sayed, El-Sepai, Fawzi Abdallah
Format: Article
Language:English
Subjects:
Ciprofloxacin
Cobalt thiocyanate
Ion-pair
Levofloxacin
Norfloxacin
Pharmaceutical analysis
Spectrophotometry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new simple extractive spectrophotometric method has been developed for the determination of levofloxacin (I), norfloxacin (II), and ciprofloxacin (III) in pure form and tablets. The method is based on the formation of blue‐colored ion‐pair associates between the drugs and the inorganic complex, cobalt (II) thiocyanate, at pH 2.5. Those ion‐pair associates are readily extracted into an n‐butanol‐dichloromethane solvent mixture (3.5:6.5) and determined spectrophotometrically at 623 nm. The concentration range is 20–240 μg mL−1 for the three studied drugs. The proposed method was successfully applied to determine these drugs in their tablet formulations, and the results are in good agreement with those obtained by the reference methods.
ISSN:0009-4536
2192-6549
DOI:10.1002/jccs.200500012