Pyrazolones as Building Blocks in Heterocyclic Synthesis: Synthesis of New Pyrazolopyran, Pyrazolopyridazine and Pyrazole Derivatives of Expected Antifungicidal Activity

A series of new pyrazolone and pyrazole derivatives with expected antifungicidal activity have been prepared through the reactions 3‐phenyl‐1‐H‐pyrazol‐5(4H)‐one (3) and 4‐(dimethylaminomethylene)‐3‐phenyl‐1H‐pyrazol‐5(4H)‐one (5) with a variety of electrophilic reagents and nucleophilic reagents. T...

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Bibliographic Details
Published in:Journal of the Chinese Chemical Society (Taipei) 2012-01, Vol.59 (1), p.72-80
Main Authors: Ramiz, Mahmoud. M. M., Hafiz, Ibrahim. S. Abdel, Reheim, Mohamed. A. M. Abdel, Gaber, Hatem M.
Format: Article
Language:English
Subjects:
Pyrazolone
Pyrazolopyran and pyrazolopyridazine and pyrazole derivatives
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Summary:A series of new pyrazolone and pyrazole derivatives with expected antifungicidal activity have been prepared through the reactions 3‐phenyl‐1‐H‐pyrazol‐5(4H)‐one (3) and 4‐(dimethylaminomethylene)‐3‐phenyl‐1H‐pyrazol‐5(4H)‐one (5) with a variety of electrophilic reagents and nucleophilic reagents. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and mass spectral studies. A series of new pyrazolone and pyrazole derivatives with expected antifungicidal activity have been prepared through the reactions 3‐phenyl‐1‐H‐pyrazol‐5(4H)‐one (3) and 4‐(dimethylaminomethylene)‐3‐phenyl‐1H‐pyrazol‐5(4H)‐one (5) with a variety of electrophilic reagents and nucleophilic reagents.
ISSN:0009-4536
2192-6549
DOI:10.1002/jccs.201100194