Synthesis and Urease Inhibition Studies of Barbituric and Thiobarbituric Acid Derived Sulphonamides

Various novel barbituric and thiobarbituric acid derived sulphonamides were synthesized in excellent yield via three components single pot reaction; and these were screened for in vitro urease inhibition studies against jack bean urease. The compounds 1‐7 were found to exhibit a low to moderate acti...

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Bibliographic Details
Published in:Journal of the Chinese Chemical Society (Taipei) 2011-08, Vol.58 (4), p.528-537
Main Authors: Rauf, A., Ahmed, F., Qureshi, A. M., Aziz-ur-Rehman, Khan, A., Qadir, M. I., Choudhary, M. I., Chohan, Z. H., Youssoufid, M. H., Haddad, T. Ben
Format: Article
Language:English
Subjects:
Antiurease
Barbituric and thiobarbituric acids based sulphonamides
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Summary:Various novel barbituric and thiobarbituric acid derived sulphonamides were synthesized in excellent yield via three components single pot reaction; and these were screened for in vitro urease inhibition studies against jack bean urease. The compounds 1‐7 were found to exhibit a low to moderate activity whereas compounds 8‐14 showed a significant activity (88.3‐99.9% inhibition determined at 500 μM concentration). Structures of the synthesized compounds were confirmed by 1H‐NMR, 13C‐NMR, mass spectrometry and elemental analysis data. It reports the synthesis of novel barbituric and thiobarbituric acid derived sulphonamides via three components single pot reaction; and these were screened for in vitro urease inhibition studies against jack bean urease.
ISSN:0009-4536
2192-6549
DOI:10.1002/jccs.201190017