The Co( OH ) 2 @ Glu‐TSC nanoflakes enhance the apoptosis in hepatoma G2 cell

The aim of the present study was to evaluate the impact of cobalt hydroxide nanoparticles conjugated with glutamic acid and thiosemicarbazides (Co(OH) 2 @ Glu‐TSC) on Hepatoma G2 (HpG2) cancer cell lines. The effect of different concentrations of Co(OH) 2 @Glu‐TSC nanoparticles on the growth of Huma...

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Published in:Journal of the Chinese Chemical Society (Taipei) 2021-08, Vol.68 (8), p.1574-1585
Main Authors: Shahrokhshahi, Asal, Salehzadeh, Ali, Vaziri, Hamid Reza, Moradi‐Shoeili, Zeinab
Format: Article
Language:English
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Summary:The aim of the present study was to evaluate the impact of cobalt hydroxide nanoparticles conjugated with glutamic acid and thiosemicarbazides (Co(OH) 2 @ Glu‐TSC) on Hepatoma G2 (HpG2) cancer cell lines. The effect of different concentrations of Co(OH) 2 @Glu‐TSC nanoparticles on the growth of Human Embryonic Kidney‐293 (HEK‐293) normal cells and HpG2 cancer cells was evaluated. The half maximal inhibitory concentration of Co(OH) 2 @Glu‐TSC nanoparticle on HEK‐293 and HepG2 was 701.65 μg/ml and 133.62 μg/ml, respectively. The percentage of HpG2 living cells in untreated group was significantly higher than that in Co(OH) 2 @Glu‐TSC‐treated group (95.5 vs. 59.5%; p  
ISSN:0009-4536
2192-6549
DOI:10.1002/jccs.202000516