Synthesis, Characterization, and In Vitro Microbial Evaluation of Some New 4 H ‐Chromene and Quinoline Derivatives of 1 H ‐Pyrazole

A new series of nine derivatives of 4 H ‐pyrano[3,2‐ c ]chromene and 12 derivatives of N ‐thiazolyl‐4 H ‐quinoline of 1 H ‐pyrazole has been synthesized by one pot base catalyzed cyclocondensation reaction of 1 H ‐pyrazole‐4‐carbaldehyde, malononitrile, and 4‐hydroxy coumarin or β‐enaminones, respec...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2012-09, Vol.49 (5), p.1169-1178
Main Authors: Thumar, Nilesh J., Patel, Manish P.
Format: Article
Language:English
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Summary:A new series of nine derivatives of 4 H ‐pyrano[3,2‐ c ]chromene and 12 derivatives of N ‐thiazolyl‐4 H ‐quinoline of 1 H ‐pyrazole has been synthesized by one pot base catalyzed cyclocondensation reaction of 1 H ‐pyrazole‐4‐carbaldehyde, malononitrile, and 4‐hydroxy coumarin or β‐enaminones, respectively. All the synthesized compounds were characterized by elemental analysis, FT‐IR, 1 H NMR, 13 C NMR spectral data and were further screened, against a panel of pathogenic strains of bacteria and fungi.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.1038