AgNO 3 Catalyzed Regio‐Selective Synthesis of 3‐Alkyl/Aryl‐idene‐3,4‐dihydro‐4‐tosyl‐2H‐1,4‐Benzoxazine: Novel Anti‐Tubercular Scaffolds

A facile and efficient method for the construction of 3‐alkyl/aryl substituted 1,4‐benzoxazine and benzoxazepine via AgNO 3 catalyzed cyclization of propargyloxy sulfonamides and their anti‐tubercular activity against Mycobacterium tuberculosis H 37 R V is described. This cyclization proceeds throug...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2016-09, Vol.53 (5), p.1611-1616
Main Authors: Karunanidhi, Sivanandhan, Karpoormath, Rajshekhar, Bera, Milan, Rane, Rajesh A., Palkar, Mahesh B.
Format: Article
Language:English
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Summary:A facile and efficient method for the construction of 3‐alkyl/aryl substituted 1,4‐benzoxazine and benzoxazepine via AgNO 3 catalyzed cyclization of propargyloxy sulfonamides and their anti‐tubercular activity against Mycobacterium tuberculosis H 37 R V is described. This cyclization proceeds through 6‐ exo ‐dig manner to generate the products in moderate to good yields.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.2472