Synthesis of pyrazolopyridine 3-carboxylates by Friedlander condensation

A series of 1,3,6‐trisubstituted and 1,3,5,6‐tetrasubstituted pyrazolo [3,4‐b] pyridines 5 have been synthesized by series of reactions on 1‐phenyl‐3‐carboxylate pyrazolone to obtain o‐aminoaldehyde, which undergo facile condensation with various α‐methylene ketones, nitriles, and esters, furnish fu...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2010-03, Vol.47 (2), p.287-291
Main Authors: Toche, Raghunath B., Bhavsar, Dinesh C., Kazi, Muddassar A., Bagul, Sandeep M., Jachak, Madhukar N.
Format: Article
Language:English
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Summary:A series of 1,3,6‐trisubstituted and 1,3,5,6‐tetrasubstituted pyrazolo [3,4‐b] pyridines 5 have been synthesized by series of reactions on 1‐phenyl‐3‐carboxylate pyrazolone to obtain o‐aminoaldehyde, which undergo facile condensation with various α‐methylene ketones, nitriles, and esters, furnish fused pyridine derivative in good yield. J. Heterocyclic Chem., (2010).
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.294