Design, Synthesis, and Evaluation of the Anticancer Properties of a Novel Series of α‐(Benzoylamino)‐β‐substituted Acrylic Amide Derivatives of Pyrazolo[1,5‐a]pyrimidine

A novel series of α‐(benzoylamino)‐β‐substituted acrylic amide derivatives of pyrazolo[1,5‐a]pyrimidine has been synthesized using a convergent multistep synthesis. The synthesized compounds were characterized by 1H NMR, 13C NMR, ESI‐MS, and IR analyses. Those new compounds were screened for their i...

Full description

Saved in:
Bibliographic Details
Published in:Journal of heterocyclic chemistry 2018-01, Vol.55 (1), p.214-225
Main Authors: Sasikumar, A., Mohanasrinivasan, V., Ajeesh Kumar, A. K., Krishnaswamy, D.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c1849-5b888eb8ed12b8768a27dd7c308f14a8ccff4874001aa508d1663e57b299a3b73
cites cdi_FETCH-LOGICAL-c1849-5b888eb8ed12b8768a27dd7c308f14a8ccff4874001aa508d1663e57b299a3b73
container_end_page 225
container_issue 1
container_start_page 214
container_title Journal of heterocyclic chemistry
container_volume 55
creator Sasikumar, A.
Mohanasrinivasan, V.
Ajeesh Kumar, A. K.
Krishnaswamy, D.
description A novel series of α‐(benzoylamino)‐β‐substituted acrylic amide derivatives of pyrazolo[1,5‐a]pyrimidine has been synthesized using a convergent multistep synthesis. The synthesized compounds were characterized by 1H NMR, 13C NMR, ESI‐MS, and IR analyses. Those new compounds were screened for their in vitro antiproliferative activity using an MTT assay analysis. Out of nine derivatives synthesized in the current study, compounds 13g, 13d, 13h, and 13i exhibited the greatest anticancer activities in HeLa and HepG2 cell lines. The in vitro anticancer activity of compound 13g against HeLa, HepG2, and MCF‐7 cell lines is superior to the marketed drugs paclitaxel and SAHA.
doi_str_mv 10.1002/jhet.3029
format article
fullrecord <record><control><sourceid>wiley_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1002_jhet_3029</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>JHET3029</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1849-5b888eb8ed12b8768a27dd7c308f14a8ccff4874001aa508d1663e57b299a3b73</originalsourceid><addsrcrecordid>eNp1UEtOwzAQtRBIlMKCG3gJUlPsfBpnWWihoAqQAAkJochxJuAqtSs7DUpXHIGrAPfgEJwEh7JlM7_33szoIbRPSZ8S4h_NnqHqB8RPNlCHJmHgRTQJNlHHYb5HI_9-G-1YO3MtDeK4gz5HYOWT6uGbRlXPrrY9zFWOxzUvl7ySWmFdYIfgoaqk4EqAwddGL8BUEmwLcnypayjxDZi_ydf79-vbwTGolW5KPpdKH7rB14cLdpnZSlbLCnI8FKYppcDDucwBj5y8dhfr9Y7rxvCVLvUD7UVOxx8XjZGOKBXsoq2Clxb2_nIX3Z2Ob08m3vTq7PxkOPUEZWHiRRljDDIGOfUzFg8Y9-M8j0VAWEFDzoQoipDFISGU84iwnA4GAURx5icJD7I46KLD9V5htLUGinThXuCmSSlJW7fT1u20ddtxj9bcF1lC8z8xvZiMb38VP1hlipA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Design, Synthesis, and Evaluation of the Anticancer Properties of a Novel Series of α‐(Benzoylamino)‐β‐substituted Acrylic Amide Derivatives of Pyrazolo[1,5‐a]pyrimidine</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>Sasikumar, A. ; Mohanasrinivasan, V. ; Ajeesh Kumar, A. K. ; Krishnaswamy, D.</creator><creatorcontrib>Sasikumar, A. ; Mohanasrinivasan, V. ; Ajeesh Kumar, A. K. ; Krishnaswamy, D.</creatorcontrib><description>A novel series of α‐(benzoylamino)‐β‐substituted acrylic amide derivatives of pyrazolo[1,5‐a]pyrimidine has been synthesized using a convergent multistep synthesis. The synthesized compounds were characterized by 1H NMR, 13C NMR, ESI‐MS, and IR analyses. Those new compounds were screened for their in vitro antiproliferative activity using an MTT assay analysis. Out of nine derivatives synthesized in the current study, compounds 13g, 13d, 13h, and 13i exhibited the greatest anticancer activities in HeLa and HepG2 cell lines. The in vitro anticancer activity of compound 13g against HeLa, HepG2, and MCF‐7 cell lines is superior to the marketed drugs paclitaxel and SAHA.</description><identifier>ISSN: 0022-152X</identifier><identifier>EISSN: 1943-5193</identifier><identifier>DOI: 10.1002/jhet.3029</identifier><language>eng</language><ispartof>Journal of heterocyclic chemistry, 2018-01, Vol.55 (1), p.214-225</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1849-5b888eb8ed12b8768a27dd7c308f14a8ccff4874001aa508d1663e57b299a3b73</citedby><cites>FETCH-LOGICAL-c1849-5b888eb8ed12b8768a27dd7c308f14a8ccff4874001aa508d1663e57b299a3b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Sasikumar, A.</creatorcontrib><creatorcontrib>Mohanasrinivasan, V.</creatorcontrib><creatorcontrib>Ajeesh Kumar, A. K.</creatorcontrib><creatorcontrib>Krishnaswamy, D.</creatorcontrib><title>Design, Synthesis, and Evaluation of the Anticancer Properties of a Novel Series of α‐(Benzoylamino)‐β‐substituted Acrylic Amide Derivatives of Pyrazolo[1,5‐a]pyrimidine</title><title>Journal of heterocyclic chemistry</title><description>A novel series of α‐(benzoylamino)‐β‐substituted acrylic amide derivatives of pyrazolo[1,5‐a]pyrimidine has been synthesized using a convergent multistep synthesis. The synthesized compounds were characterized by 1H NMR, 13C NMR, ESI‐MS, and IR analyses. Those new compounds were screened for their in vitro antiproliferative activity using an MTT assay analysis. Out of nine derivatives synthesized in the current study, compounds 13g, 13d, 13h, and 13i exhibited the greatest anticancer activities in HeLa and HepG2 cell lines. The in vitro anticancer activity of compound 13g against HeLa, HepG2, and MCF‐7 cell lines is superior to the marketed drugs paclitaxel and SAHA.</description><issn>0022-152X</issn><issn>1943-5193</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1UEtOwzAQtRBIlMKCG3gJUlPsfBpnWWihoAqQAAkJochxJuAqtSs7DUpXHIGrAPfgEJwEh7JlM7_33szoIbRPSZ8S4h_NnqHqB8RPNlCHJmHgRTQJNlHHYb5HI_9-G-1YO3MtDeK4gz5HYOWT6uGbRlXPrrY9zFWOxzUvl7ySWmFdYIfgoaqk4EqAwddGL8BUEmwLcnypayjxDZi_ydf79-vbwTGolW5KPpdKH7rB14cLdpnZSlbLCnI8FKYppcDDucwBj5y8dhfr9Y7rxvCVLvUD7UVOxx8XjZGOKBXsoq2Clxb2_nIX3Z2Ob08m3vTq7PxkOPUEZWHiRRljDDIGOfUzFg8Y9-M8j0VAWEFDzoQoipDFISGU84iwnA4GAURx5icJD7I46KLD9V5htLUGinThXuCmSSlJW7fT1u20ddtxj9bcF1lC8z8xvZiMb38VP1hlipA</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Sasikumar, A.</creator><creator>Mohanasrinivasan, V.</creator><creator>Ajeesh Kumar, A. K.</creator><creator>Krishnaswamy, D.</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201801</creationdate><title>Design, Synthesis, and Evaluation of the Anticancer Properties of a Novel Series of α‐(Benzoylamino)‐β‐substituted Acrylic Amide Derivatives of Pyrazolo[1,5‐a]pyrimidine</title><author>Sasikumar, A. ; Mohanasrinivasan, V. ; Ajeesh Kumar, A. K. ; Krishnaswamy, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1849-5b888eb8ed12b8768a27dd7c308f14a8ccff4874001aa508d1663e57b299a3b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sasikumar, A.</creatorcontrib><creatorcontrib>Mohanasrinivasan, V.</creatorcontrib><creatorcontrib>Ajeesh Kumar, A. K.</creatorcontrib><creatorcontrib>Krishnaswamy, D.</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of heterocyclic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sasikumar, A.</au><au>Mohanasrinivasan, V.</au><au>Ajeesh Kumar, A. K.</au><au>Krishnaswamy, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Design, Synthesis, and Evaluation of the Anticancer Properties of a Novel Series of α‐(Benzoylamino)‐β‐substituted Acrylic Amide Derivatives of Pyrazolo[1,5‐a]pyrimidine</atitle><jtitle>Journal of heterocyclic chemistry</jtitle><date>2018-01</date><risdate>2018</risdate><volume>55</volume><issue>1</issue><spage>214</spage><epage>225</epage><pages>214-225</pages><issn>0022-152X</issn><eissn>1943-5193</eissn><abstract>A novel series of α‐(benzoylamino)‐β‐substituted acrylic amide derivatives of pyrazolo[1,5‐a]pyrimidine has been synthesized using a convergent multistep synthesis. The synthesized compounds were characterized by 1H NMR, 13C NMR, ESI‐MS, and IR analyses. Those new compounds were screened for their in vitro antiproliferative activity using an MTT assay analysis. Out of nine derivatives synthesized in the current study, compounds 13g, 13d, 13h, and 13i exhibited the greatest anticancer activities in HeLa and HepG2 cell lines. The in vitro anticancer activity of compound 13g against HeLa, HepG2, and MCF‐7 cell lines is superior to the marketed drugs paclitaxel and SAHA.</abstract><doi>10.1002/jhet.3029</doi><tpages>12</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0022-152X
ispartof Journal of heterocyclic chemistry, 2018-01, Vol.55 (1), p.214-225
issn 0022-152X
1943-5193
language eng
recordid cdi_crossref_primary_10_1002_jhet_3029
source Wiley-Blackwell Read & Publish Collection
title Design, Synthesis, and Evaluation of the Anticancer Properties of a Novel Series of α‐(Benzoylamino)‐β‐substituted Acrylic Amide Derivatives of Pyrazolo[1,5‐a]pyrimidine
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T18%3A12%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wiley_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Design,%20Synthesis,%20and%20Evaluation%20of%20the%20Anticancer%20Properties%20of%20a%20Novel%20Series%20of%20%CE%B1%E2%80%90(Benzoylamino)%E2%80%90%CE%B2%E2%80%90substituted%20Acrylic%20Amide%20Derivatives%20of%20Pyrazolo%5B1,5%E2%80%90a%5Dpyrimidine&rft.jtitle=Journal%20of%20heterocyclic%20chemistry&rft.au=Sasikumar,%20A.&rft.date=2018-01&rft.volume=55&rft.issue=1&rft.spage=214&rft.epage=225&rft.pages=214-225&rft.issn=0022-152X&rft.eissn=1943-5193&rft_id=info:doi/10.1002/jhet.3029&rft_dat=%3Cwiley_cross%3EJHET3029%3C/wiley_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c1849-5b888eb8ed12b8768a27dd7c308f14a8ccff4874001aa508d1663e57b299a3b73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true