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Synthesis and Antimicrobial Activity of Novel Derivatives of 7‐aryl‐10‐thioxo‐7, 10, 11, 12 – tertahydro‐9 H ‐benzo[ H ] pyrimido [4,5‐ b ] quinoline‐8‐one
A highly competent synthesis of novel 7‐aryl‐10‐thioxo‐7, 10, 11, 12‐tertahydro‐9 H ‐benzo [ H ] pyrimido [4, 5‐ b ] quinoline‐8‐one derivatives has been reported through a Knoevenagel condensation followed by Michael addition and subsequent cyclization using ethanol:acetic acid (8:2 v /v). The men...
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| Published in: | Journal of heterocyclic chemistry 2018-03, Vol.55 (3), p.692-698 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c749-e89b6c7596549bdb2f6f9b61fc8fecd9c880e9b86a3a72bf9fa35bcf93cc50cb3 |
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| cites | cdi_FETCH-LOGICAL-c749-e89b6c7596549bdb2f6f9b61fc8fecd9c880e9b86a3a72bf9fa35bcf93cc50cb3 |
| container_end_page | 698 |
| container_issue | 3 |
| container_start_page | 692 |
| container_title | Journal of heterocyclic chemistry |
| container_volume | 55 |
| creator | Kumbhar, Digambar Chandam, Dattatray Patil, Reshma Jadhav, Sunetra Patil, Dayanand Patravale, Ajinkya Deshmukh, Madhukar |
| description | A highly competent synthesis of novel 7‐aryl‐10‐thioxo‐7, 10, 11, 12‐tertahydro‐9
H
‐benzo [
H
] pyrimido [4, 5‐
b
] quinoline‐8‐one derivatives has been reported through a Knoevenagel condensation followed by Michael addition and subsequent cyclization using ethanol:acetic acid (8:2
v
/v). The mentioned protocol has advantages like high yields, cleaner reactions, operational simplicity, and environment friendliness. Moreover, these compounds were further screened against the plant pathogenic fungi like
C
olletotrichum
truncatum
,
U
stilago
maydis
,
Trichosporon
,
Trichothecium sp
.,
Aspergillus oryze
,
Aspergillus terreus
, and
A
spergillus
niger
by agar well method bioassay. The results were elaborated for minimum inhibitory concentration determination using agar dilution method against fungal strains
C. truncatum
and
U. maydis
as well as broth dilution method for bacteria species Gram‐positive
Bacillus megaterium
and Gram‐negative
Proteus vulgaris
. Most of the tested compounds showed promising results towards the antimicrobial activity. |
| doi_str_mv | 10.1002/jhet.3089 |
| format | article |
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H
‐benzo [
H
] pyrimido [4, 5‐
b
] quinoline‐8‐one derivatives has been reported through a Knoevenagel condensation followed by Michael addition and subsequent cyclization using ethanol:acetic acid (8:2
v
/v). The mentioned protocol has advantages like high yields, cleaner reactions, operational simplicity, and environment friendliness. Moreover, these compounds were further screened against the plant pathogenic fungi like
C
olletotrichum
truncatum
,
U
stilago
maydis
,
Trichosporon
,
Trichothecium sp
.,
Aspergillus oryze
,
Aspergillus terreus
, and
A
spergillus
niger
by agar well method bioassay. The results were elaborated for minimum inhibitory concentration determination using agar dilution method against fungal strains
C. truncatum
and
U. maydis
as well as broth dilution method for bacteria species Gram‐positive
Bacillus megaterium
and Gram‐negative
Proteus vulgaris
. Most of the tested compounds showed promising results towards the antimicrobial activity.</description><identifier>ISSN: 0022-152X</identifier><identifier>EISSN: 1943-5193</identifier><identifier>DOI: 10.1002/jhet.3089</identifier><language>eng</language><ispartof>Journal of heterocyclic chemistry, 2018-03, Vol.55 (3), p.692-698</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c749-e89b6c7596549bdb2f6f9b61fc8fecd9c880e9b86a3a72bf9fa35bcf93cc50cb3</citedby><cites>FETCH-LOGICAL-c749-e89b6c7596549bdb2f6f9b61fc8fecd9c880e9b86a3a72bf9fa35bcf93cc50cb3</cites><orcidid>0000-0001-7097-2356</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Kumbhar, Digambar</creatorcontrib><creatorcontrib>Chandam, Dattatray</creatorcontrib><creatorcontrib>Patil, Reshma</creatorcontrib><creatorcontrib>Jadhav, Sunetra</creatorcontrib><creatorcontrib>Patil, Dayanand</creatorcontrib><creatorcontrib>Patravale, Ajinkya</creatorcontrib><creatorcontrib>Deshmukh, Madhukar</creatorcontrib><title>Synthesis and Antimicrobial Activity of Novel Derivatives of 7‐aryl‐10‐thioxo‐7, 10, 11, 12 – tertahydro‐9 H ‐benzo[ H ] pyrimido [4,5‐ b ] quinoline‐8‐one</title><title>Journal of heterocyclic chemistry</title><description>A highly competent synthesis of novel 7‐aryl‐10‐thioxo‐7, 10, 11, 12‐tertahydro‐9
H
‐benzo [
H
] pyrimido [4, 5‐
b
] quinoline‐8‐one derivatives has been reported through a Knoevenagel condensation followed by Michael addition and subsequent cyclization using ethanol:acetic acid (8:2
v
/v). The mentioned protocol has advantages like high yields, cleaner reactions, operational simplicity, and environment friendliness. Moreover, these compounds were further screened against the plant pathogenic fungi like
C
olletotrichum
truncatum
,
U
stilago
maydis
,
Trichosporon
,
Trichothecium sp
.,
Aspergillus oryze
,
Aspergillus terreus
, and
A
spergillus
niger
by agar well method bioassay. The results were elaborated for minimum inhibitory concentration determination using agar dilution method against fungal strains
C. truncatum
and
U. maydis
as well as broth dilution method for bacteria species Gram‐positive
Bacillus megaterium
and Gram‐negative
Proteus vulgaris
. Most of the tested compounds showed promising results towards the antimicrobial activity.</description><issn>0022-152X</issn><issn>1943-5193</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNotkM1KAzEUhYMoWKsL3yBboVOTyfxlWepPhaILuxCKDEkmoSnjpE5icVz1EQo-iO_UJ_EOuji5N9-B5N6D0CUlY0pIfL1e6TBmpOBHaEB5wqKUcnaMBuDFEU3jl1N05v0arpTl-QD9PHdNWGlvPRZNhSdNsG9WtU5aUeOJCnZrQ4edwY9uq2t8o1u7FUC172F-2O1F29VQKIEjrKz7dNDkI0wJiIJifNh946DbIFZd1fY2xzOAe6mbL7eE_hVvuhY-rhxeJqMULCwBvn_YxtW20QAKkGv0OToxovb64r8O0eLudjGdRfOn-4fpZB6pPOGRLrjMVJ7yLE24rGRsMgOEGlUYrSquioJoLotMMJHH0nAjWCqV4UyplCjJhujq71mIwvtWm3ID88GqJSVlH3TZB132QbNfljd7OA</recordid><startdate>201803</startdate><enddate>201803</enddate><creator>Kumbhar, Digambar</creator><creator>Chandam, Dattatray</creator><creator>Patil, Reshma</creator><creator>Jadhav, Sunetra</creator><creator>Patil, Dayanand</creator><creator>Patravale, Ajinkya</creator><creator>Deshmukh, Madhukar</creator><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0001-7097-2356</orcidid></search><sort><creationdate>201803</creationdate><title>Synthesis and Antimicrobial Activity of Novel Derivatives of 7‐aryl‐10‐thioxo‐7, 10, 11, 12 – tertahydro‐9 H ‐benzo[ H ] pyrimido [4,5‐ b ] quinoline‐8‐one</title><author>Kumbhar, Digambar ; Chandam, Dattatray ; Patil, Reshma ; Jadhav, Sunetra ; Patil, Dayanand ; Patravale, Ajinkya ; Deshmukh, Madhukar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c749-e89b6c7596549bdb2f6f9b61fc8fecd9c880e9b86a3a72bf9fa35bcf93cc50cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kumbhar, Digambar</creatorcontrib><creatorcontrib>Chandam, Dattatray</creatorcontrib><creatorcontrib>Patil, Reshma</creatorcontrib><creatorcontrib>Jadhav, Sunetra</creatorcontrib><creatorcontrib>Patil, Dayanand</creatorcontrib><creatorcontrib>Patravale, Ajinkya</creatorcontrib><creatorcontrib>Deshmukh, Madhukar</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of heterocyclic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumbhar, Digambar</au><au>Chandam, Dattatray</au><au>Patil, Reshma</au><au>Jadhav, Sunetra</au><au>Patil, Dayanand</au><au>Patravale, Ajinkya</au><au>Deshmukh, Madhukar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and Antimicrobial Activity of Novel Derivatives of 7‐aryl‐10‐thioxo‐7, 10, 11, 12 – tertahydro‐9 H ‐benzo[ H ] pyrimido [4,5‐ b ] quinoline‐8‐one</atitle><jtitle>Journal of heterocyclic chemistry</jtitle><date>2018-03</date><risdate>2018</risdate><volume>55</volume><issue>3</issue><spage>692</spage><epage>698</epage><pages>692-698</pages><issn>0022-152X</issn><eissn>1943-5193</eissn><abstract>A highly competent synthesis of novel 7‐aryl‐10‐thioxo‐7, 10, 11, 12‐tertahydro‐9
H
‐benzo [
H
] pyrimido [4, 5‐
b
] quinoline‐8‐one derivatives has been reported through a Knoevenagel condensation followed by Michael addition and subsequent cyclization using ethanol:acetic acid (8:2
v
/v). The mentioned protocol has advantages like high yields, cleaner reactions, operational simplicity, and environment friendliness. Moreover, these compounds were further screened against the plant pathogenic fungi like
C
olletotrichum
truncatum
,
U
stilago
maydis
,
Trichosporon
,
Trichothecium sp
.,
Aspergillus oryze
,
Aspergillus terreus
, and
A
spergillus
niger
by agar well method bioassay. The results were elaborated for minimum inhibitory concentration determination using agar dilution method against fungal strains
C. truncatum
and
U. maydis
as well as broth dilution method for bacteria species Gram‐positive
Bacillus megaterium
and Gram‐negative
Proteus vulgaris
. Most of the tested compounds showed promising results towards the antimicrobial activity.</abstract><doi>10.1002/jhet.3089</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7097-2356</orcidid></addata></record> |
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| ispartof | Journal of heterocyclic chemistry, 2018-03, Vol.55 (3), p.692-698 |
| issn | 0022-152X 1943-5193 |
| language | eng |
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| source | Wiley |
| title | Synthesis and Antimicrobial Activity of Novel Derivatives of 7‐aryl‐10‐thioxo‐7, 10, 11, 12 – tertahydro‐9 H ‐benzo[ H ] pyrimido [4,5‐ b ] quinoline‐8‐one |
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