TiO 2 ‐Nanoparticles Catalyzed Synthesis of New Trifluoromethyl‐4,5‐dihydro‐1,2,4‐oxadiazoles and Trifluoromethyl‐1,2,4‐oxadiazoles

Synthesis of a new series of trifluoromethyl‐4,5‐dihydro‐1,2,4‐oxadiazoles and trifluoromethyl‐1,2,4‐oxadiazoles have been described by utilizing the reactions between amidoximes and trifluoroacetimidoyl chlorides. Trifluoromethyl‐4,5‐dihydro‐1,2,4‐oxadiazoles have been synthesized under mild condit...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2018-07, Vol.55 (7), p.1702-1708
Main Authors: Darehkordi, Ali, Ramezani, Mahin, Rahmani, Fariba
Format: Article
Language:English
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Summary:Synthesis of a new series of trifluoromethyl‐4,5‐dihydro‐1,2,4‐oxadiazoles and trifluoromethyl‐1,2,4‐oxadiazoles have been described by utilizing the reactions between amidoximes and trifluoroacetimidoyl chlorides. Trifluoromethyl‐4,5‐dihydro‐1,2,4‐oxadiazoles have been synthesized under mild conditions such as Na 2 CO 3 , THF‐H 2 O, and titanium dioxide nanoparticles as catalyst in good to excellent yields. Also, trifluoromethyl‐1,2,4‐oxadiazoles have been synthesized directly from reaction of amidoximes and trifluoroacetimidoyl chlorides in a one‐pot manner in present of NaH, THF, and titanium dioxide nanoparticle as catalyst.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.3207