An efficient one‐pot three‐component synthesis of 4‐phenyl hexahydro‐ 1 H ‐pyrano[2,3‐ d ]pyrimidin‐2(8a H )‐one derivatives

magnified image An efficient method for the synthesis of a series of 4‐phenylhexahydro‐ 1H ‐pyrano[2,3‐ d ]pyrimidin‐2(8a H )‐one derivatives via the one‐pot three‐component reaction of aromatic aldehydes, urea or thiourea and 3,4‐dihydro‐2 H ‐pyran in DMF/CH 3 CN using p ‐TSA catalyst is described....

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2010-05, Vol.47 (3), p.687-690
Main Authors: Vuppalapati, Srinivasu V. N., Bantu Lingaiah, Rajashekar, Kantevari, Srinivas
Format: Article
Language:English
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Summary:magnified image An efficient method for the synthesis of a series of 4‐phenylhexahydro‐ 1H ‐pyrano[2,3‐ d ]pyrimidin‐2(8a H )‐one derivatives via the one‐pot three‐component reaction of aromatic aldehydes, urea or thiourea and 3,4‐dihydro‐2 H ‐pyran in DMF/CH 3 CN using p ‐TSA catalyst is described. Although three chiral centers are created, only one diastereomer is formed in a highly selective way. This method has several advantages such as higher yield, lower cost, and shorter reaction times. J. Heterocyclic Chem. (2010)
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.379