Engaging thieno[2,3‐b]indole‐2,3‐dione for the efficient synthesis of spiro[indoline‐3,4′‐thiopyrano[2,3‐b]indole] by reaction with N‐substituted isatilidenes

A simple and efficient method, proceeding through a new mechanistic pathway, for the synthesis of spiro[indoline‐3,4‐thiopyrano[2.3‐b]indole derivatives have been developed by exploiting the reaction of thieno[2,3‐b]indole‐2,3‐dione with N‐substituted isatilidenes. The compounds synthesized have bee...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2021-01, Vol.58 (1), p.48-55
Main Authors: Thomas, Noble V., Sathi, Vidya, Deepthi, Ani, Leena, Sruthi, Chopra, Sidharth
Format: Article
Language:English
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Summary:A simple and efficient method, proceeding through a new mechanistic pathway, for the synthesis of spiro[indoline‐3,4‐thiopyrano[2.3‐b]indole derivatives have been developed by exploiting the reaction of thieno[2,3‐b]indole‐2,3‐dione with N‐substituted isatilidenes. The compounds synthesized have been screened for antibacterial activity. The generality of the reaction and mechanistic rationale are presented.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.4147