Imidazo[1,2‐a]pyridine as a promising scaffold for the development of antibacterial agents

• Published in: Journal of heterocyclic chemistry 2022-12, Vol.59 (12), p.2051-2075
• Main Authors: Mishra, Nilima Priyadarsini, Mohapatra, Seetaram, Das, Tapaswini, Nayak, Sabita
• Format: Article
• Language: English
• ISSN: 0022-152X; 1943-5193
• DOI: 10.1002/jhet.4534

The fascinating molecular structure and versatile bioactivity of imidazo[1,2‐a]pyridine scaffold attracts the scientific community to develop new imidazo[1,2‐a]pyridine based antibacterial agent in current situation. This systematic review provides a deep insight into the recent advances of imidazo[1,2‐a]pyridine derivatives and its antibacterial activities from 2010 to 2021. Moreover, the structure–activity relationship and synthetic approaches are also cautiously summarized throughout the review which affords a clear vision for the medicinal chemists to design new antibacterial agents. The fascinating molecular structure and versatile bioactivity of imidazo[1,2‐a]pyridine scaffold attracts the scientific community to develop new imidazo[1,2‐a]pyridine based antibacterial agent in current situation. This systematic review provides a deep insight into the recent advances of imidazo[1,2‐a]pyridine derivatives and its antibacterial activities from 2010 to 2021. Moreover, the structure–activity relationship and synthetic approaches are also cautiously summarized throughout the review which affords a clear vision for the medicinal chemists to design new antibacterial agents.