Loading…

Convenient synthesis and antibacterial evaluation of new bipyrazolyl and pyrazolopyridazine derivatives utilizing 4‐acetyl‐5‐methyl‐ N ‐phenyl‐1‐( p ‐tolyl)‐ 1 H ‐pyrazole‐3‐carboxamide as a versatile precursor

4‐(3‐(Dimethylamino)acryloyl)‐5‐methyl‐ N ‐phenyl‐1‐( p ‐tolyl)‐1 H ‐pyrazole‐3‐carboxamide was prepared via refluxing of 4‐acetyl‐5‐methyl‐ N ‐phenyl‐1‐( p ‐tolyl)‐1 H ‐pyrazole‐3‐carboxamide with dimethylformamide dimethyl acetal. The target bipyrazoles were obtained from regioselective reaction o...

Full description

Saved in:
Bibliographic Details
Published in:Journal of heterocyclic chemistry 2024-07, Vol.61 (7), p.1150-1158
Main Authors: Kamel, Monica G., Helmy, Mirna T., Saleh, Fatma M., Hassaneen, Hamdi M., Shehata, Omar A., Laboud, Yara N.
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:4‐(3‐(Dimethylamino)acryloyl)‐5‐methyl‐ N ‐phenyl‐1‐( p ‐tolyl)‐1 H ‐pyrazole‐3‐carboxamide was prepared via refluxing of 4‐acetyl‐5‐methyl‐ N ‐phenyl‐1‐( p ‐tolyl)‐1 H ‐pyrazole‐3‐carboxamide with dimethylformamide dimethyl acetal. The target bipyrazoles were obtained from regioselective reaction of the latter enaminone with different hydrazonoyl halides at reflux in chloroform in the presence of trimethylamine. The regioselectivity was confirmed chemically upon refluxing with hydrazine hydrate in ethanol. The structures of the newly synthesized compounds were established on the basis of their elemental analyses and spectral data. The specified compounds were tested for antibacterial activity against gram‐negative bacteria ( Escherichia coli ) and ( Pseudomonas aeruginosa ) and a gram‐positive bacteria ( Bacillus subtilis ) and ( Staphylococcus aureus ) using disk diffusion method. Antibacterial studies revealed that compounds 8a , 10b , 10c, 11d, and 14b showed weak to moderate activity against the tested bacteria compared to ampicillin.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.4833