The synthesis of azahomotryptophane derivatives. The transformation of N-trifluoroacetyl-5-bromo-4-oxonorvaline methyl ester into 4-(imidazo[1,2-a]azinyl-3)-4-oxohomoalanine derivatives

Azatryptophane homologues, 4‐(imidazo[1,2‐a]pyridinyl‐3)‐ 9a‐9f and 4‐(imidazo[1,2‐a]pyrimidinyl‐3)‐4‐oxohomoalanine derivatives 9g‐91, were prepared from N,N‐dimethyl‐N′‐(pyridinyl‐2)‐ 6a‐6f and N,N‐dimethyl‐N‐(pyriniidinyl‐2)formamidines 6g‐6i, and (S)‐N‐trifluoroacetyl‐5‐bromo‐4‐oxonorvaline meth...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 1997-05, Vol.34 (3), p.853-856
Main Authors: Škof, Marko, Svete, Jurij, Stanovnik, Branko
Format: Article
Language:English
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Summary:Azatryptophane homologues, 4‐(imidazo[1,2‐a]pyridinyl‐3)‐ 9a‐9f and 4‐(imidazo[1,2‐a]pyrimidinyl‐3)‐4‐oxohomoalanine derivatives 9g‐91, were prepared from N,N‐dimethyl‐N′‐(pyridinyl‐2)‐ 6a‐6f and N,N‐dimethyl‐N‐(pyriniidinyl‐2)formamidines 6g‐6i, and (S)‐N‐trifluoroacetyl‐5‐bromo‐4‐oxonorvaline methyl ester (2) and its (R,S)‐isomer.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570340323