Studies on the chemical transformations of rotenoids. 6 Synthesis and antitumor-promoting activity of benzofuro[2,3-d]pyridazines fused with 1,2,4-triazole, 1,2,4-triazine and 1,2,4-triazepine

[1]Benzofuro[2,3‐d]pyridazines fused with 1,2,4‐triazole (6 and 7), 1,2,4‐triazine (8–10) and 1,2,4‐tri‐azepine (12) were prepared by the ring closure of 4‐hydrazino‐[1]benzofuro[2,3‐d]pyridazine (5), derived from naturally occurring rotenone. Compounds (la and lb) exhibited significant inhibitory a...

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Published in:Journal of heterocyclic chemistry 2001-09, Vol.38 (5), p.1097-1101
Main Authors: Nagai, Shin-Ichi, Takemoto, Satoshi, Ueda, Taisei, Mizutani, Kanako, Uozumi, Yasuhiro, Tokuda, Harukuni
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cited_by cdi_FETCH-LOGICAL-c3293-5795ebd678bd145a46502fee12e3d983d4f957c63e0a4901561723c75db421dc3
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container_issue 5
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container_title Journal of heterocyclic chemistry
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creator Nagai, Shin-Ichi
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description [1]Benzofuro[2,3‐d]pyridazines fused with 1,2,4‐triazole (6 and 7), 1,2,4‐triazine (8–10) and 1,2,4‐tri‐azepine (12) were prepared by the ring closure of 4‐hydrazino‐[1]benzofuro[2,3‐d]pyridazine (5), derived from naturally occurring rotenone. Compounds (la and lb) exhibited significant inhibitory activity against 12‐O‐tetradecanoylphorbol 13‐acetate (TPA)‐induced Epstein‐Barr virus early antigen (EBA‐EA) activation in Raji cells. In contrast, the fused [1]benzofuro[2,3‐d]pyridazines except 6c and 8 were quite inactive.
doi_str_mv 10.1002/jhet.5570380513
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title Studies on the chemical transformations of rotenoids. 6 Synthesis and antitumor-promoting activity of benzofuro[2,3-d]pyridazines fused with 1,2,4-triazole, 1,2,4-triazine and 1,2,4-triazepine
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