Synthesis of 5,6,7,8-tetrahydroindolizines via a domino-type transformation based on the rhodium catalyzed hydroformylation of N-(β-methallyl)pyrroles

Variously substituted 5,6,7,8‐tetrahydroindolizines can be easily synthesized via a domino reactions sequence under rhodium catalyzed hydroformylation of N‐(β‐methallyl)pyrroles. The later are readily prepared from properly functionalized pyrroles via phase‐transfer N‐allylation in the presence of 1...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2007-03, Vol.44 (2), p.479-482
Main Authors: Rocchiccioli, Silvia, Guazzelli, Giuditta, Lazzaroni, Raffaello, Settambolo, Roberta
Format: Article
Language:English
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Summary:Variously substituted 5,6,7,8‐tetrahydroindolizines can be easily synthesized via a domino reactions sequence under rhodium catalyzed hydroformylation of N‐(β‐methallyl)pyrroles. The later are readily prepared from properly functionalized pyrroles via phase‐transfer N‐allylation in the presence of 18‐crown‐6 and potassium tert‐butoxide.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570440234