Synthesis and antimicrobial activity of substituted [(pyrazol-4-yl)methylene]hydrazono-2,3-dihydrothiazoles and their sugar derivatives

A number of new [(pyrazol‐4‐yl)methylene]hydrazono‐2,3‐dihydrothiazole derivatives, their sugar hydrazones and N‐glycosides were synthesized. Furthermore, N‐substituted oxygenated alkyl and hydroxyl derivatives and 1,3,4,‐oxadiazoline acyclic nucleoside analogs were prepared. The newly synthesized c...

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Published in:Journal of heterocyclic chemistry 2012-01, Vol.49 (1), p.93-101
Main Authors: Abdel-Rahman, Adel A.-H., El-Sayed, Wael A., Zaki, El-Sayed G., Mohamed, Asem A., Fadda, Ahmed A.
Format: Article
Language:English
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Summary:A number of new [(pyrazol‐4‐yl)methylene]hydrazono‐2,3‐dihydrothiazole derivatives, their sugar hydrazones and N‐glycosides were synthesized. Furthermore, N‐substituted oxygenated alkyl and hydroxyl derivatives and 1,3,4,‐oxadiazoline acyclic nucleoside analogs were prepared. The newly synthesized compounds were tested for their antimicrobial activities and showed moderate to high inhibition activities. J. Heterocyclic Chem., (2012).
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.668