Loading…
High specific activity tritium labeling of vitamin D derivative RO275646
The octahydroindenone intermediate was tritium labeled using T2O isotope exchange labeling, and then elaborated to the vitamin D derivative RO275646. Though this method of labeling was expected to give the minor isomer, it was the shortest and most convenient route to the high specific activity meta...
Saved in:
Published in: | Journal of labelled compounds & radiopharmaceuticals 2005-12, Vol.48 (14), p.1013-1023 |
---|---|
Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c2524-486f618fd303e6b6780dd5c7d490016da8dfc9307b710c5a8155a6ea44a65c143 |
---|---|
cites | cdi_FETCH-LOGICAL-c2524-486f618fd303e6b6780dd5c7d490016da8dfc9307b710c5a8155a6ea44a65c143 |
container_end_page | 1023 |
container_issue | 14 |
container_start_page | 1013 |
container_title | Journal of labelled compounds & radiopharmaceuticals |
container_volume | 48 |
creator | de Keczer, Steve A. Lane, Tim S. Voronin, Tatyana Masjedizadeh, Mohammad R. |
description | The octahydroindenone intermediate was tritium labeled using T2O isotope exchange labeling, and then elaborated to the vitamin D derivative RO275646. Though this method of labeling was expected to give the minor isomer, it was the shortest and most convenient route to the high specific activity metabolically stable labeled sites. A total of 34 mCi (from two separate runs) at 64 Ci/mmol of [3H]‐RO275646 were prepared by this method. Copyright © 2005 John Wiley & Sons, Ltd. |
doi_str_mv | 10.1002/jlcr.1014 |
format | article |
fullrecord | <record><control><sourceid>istex_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1002_jlcr_1014</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ark_67375_WNG_6RBNMX9B_S</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2524-486f618fd303e6b6780dd5c7d490016da8dfc9307b710c5a8155a6ea44a65c143</originalsourceid><addsrcrecordid>eNp1kEtPAjEUhRujiYgu_AfduHAxcjt9zSwFFTQICWp015ROi8XhkXZE-fcOGaIrV_ck5zsnNwehcwJXBCDtzEsTakXYAWoRyPOEUMYOUQuoSBOWAT1GJzHOAWqPsRYaDPzsHce1Nd55g7Wp_MZXW1wFX_nPBS711JZ-OcMrh2tDL_wS3-DCBr_RNWrxZJxKLpg4RUdOl9Ge7W8bvdzdPvcGyXDcv-9dDxOT8pTVLwgnSOYKCtSKqZAZFAU3smA5ABGFzgpncgpyKgkYrjPCuRZWM6YFN4TRNrpsek1YxRisU-vgFzpsFQG1m0DtJlC7CWr2omHXOhpduqCXxse_gKSCc5LWXKfhvnxpt_8Xqodhb7JvTpqEj5X9_k3o8KGEpJKr11FfiUl39PiWd9UT_QFH7Xh1</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>High specific activity tritium labeling of vitamin D derivative RO275646</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>de Keczer, Steve A. ; Lane, Tim S. ; Voronin, Tatyana ; Masjedizadeh, Mohammad R.</creator><creatorcontrib>de Keczer, Steve A. ; Lane, Tim S. ; Voronin, Tatyana ; Masjedizadeh, Mohammad R.</creatorcontrib><description>The octahydroindenone intermediate was tritium labeled using T2O isotope exchange labeling, and then elaborated to the vitamin D derivative RO275646. Though this method of labeling was expected to give the minor isomer, it was the shortest and most convenient route to the high specific activity metabolically stable labeled sites. A total of 34 mCi (from two separate runs) at 64 Ci/mmol of [3H]‐RO275646 were prepared by this method. Copyright © 2005 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0362-4803</identifier><identifier>EISSN: 1099-1344</identifier><identifier>DOI: 10.1002/jlcr.1014</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Biological and medical sciences ; Contrast media. Radiopharmaceuticals ; exchange labeling ; Medical sciences ; minor isomer ; Pharmacology. Drug treatments ; T2O ; tritium ; vitamin D</subject><ispartof>Journal of labelled compounds & radiopharmaceuticals, 2005-12, Vol.48 (14), p.1013-1023</ispartof><rights>Copyright © 2005 John Wiley & Sons, Ltd.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2524-486f618fd303e6b6780dd5c7d490016da8dfc9307b710c5a8155a6ea44a65c143</citedby><cites>FETCH-LOGICAL-c2524-486f618fd303e6b6780dd5c7d490016da8dfc9307b710c5a8155a6ea44a65c143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17365512$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>de Keczer, Steve A.</creatorcontrib><creatorcontrib>Lane, Tim S.</creatorcontrib><creatorcontrib>Voronin, Tatyana</creatorcontrib><creatorcontrib>Masjedizadeh, Mohammad R.</creatorcontrib><title>High specific activity tritium labeling of vitamin D derivative RO275646</title><title>Journal of labelled compounds & radiopharmaceuticals</title><addtitle>J Label Compd Radiopharm</addtitle><description>The octahydroindenone intermediate was tritium labeled using T2O isotope exchange labeling, and then elaborated to the vitamin D derivative RO275646. Though this method of labeling was expected to give the minor isomer, it was the shortest and most convenient route to the high specific activity metabolically stable labeled sites. A total of 34 mCi (from two separate runs) at 64 Ci/mmol of [3H]‐RO275646 were prepared by this method. Copyright © 2005 John Wiley & Sons, Ltd.</description><subject>Biological and medical sciences</subject><subject>Contrast media. Radiopharmaceuticals</subject><subject>exchange labeling</subject><subject>Medical sciences</subject><subject>minor isomer</subject><subject>Pharmacology. Drug treatments</subject><subject>T2O</subject><subject>tritium</subject><subject>vitamin D</subject><issn>0362-4803</issn><issn>1099-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNp1kEtPAjEUhRujiYgu_AfduHAxcjt9zSwFFTQICWp015ROi8XhkXZE-fcOGaIrV_ck5zsnNwehcwJXBCDtzEsTakXYAWoRyPOEUMYOUQuoSBOWAT1GJzHOAWqPsRYaDPzsHce1Nd55g7Wp_MZXW1wFX_nPBS711JZ-OcMrh2tDL_wS3-DCBr_RNWrxZJxKLpg4RUdOl9Ge7W8bvdzdPvcGyXDcv-9dDxOT8pTVLwgnSOYKCtSKqZAZFAU3smA5ABGFzgpncgpyKgkYrjPCuRZWM6YFN4TRNrpsek1YxRisU-vgFzpsFQG1m0DtJlC7CWr2omHXOhpduqCXxse_gKSCc5LWXKfhvnxpt_8Xqodhb7JvTpqEj5X9_k3o8KGEpJKr11FfiUl39PiWd9UT_QFH7Xh1</recordid><startdate>200512</startdate><enddate>200512</enddate><creator>de Keczer, Steve A.</creator><creator>Lane, Tim S.</creator><creator>Voronin, Tatyana</creator><creator>Masjedizadeh, Mohammad R.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200512</creationdate><title>High specific activity tritium labeling of vitamin D derivative RO275646</title><author>de Keczer, Steve A. ; Lane, Tim S. ; Voronin, Tatyana ; Masjedizadeh, Mohammad R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2524-486f618fd303e6b6780dd5c7d490016da8dfc9307b710c5a8155a6ea44a65c143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Contrast media. Radiopharmaceuticals</topic><topic>exchange labeling</topic><topic>Medical sciences</topic><topic>minor isomer</topic><topic>Pharmacology. Drug treatments</topic><topic>T2O</topic><topic>tritium</topic><topic>vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Keczer, Steve A.</creatorcontrib><creatorcontrib>Lane, Tim S.</creatorcontrib><creatorcontrib>Voronin, Tatyana</creatorcontrib><creatorcontrib>Masjedizadeh, Mohammad R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Keczer, Steve A.</au><au>Lane, Tim S.</au><au>Voronin, Tatyana</au><au>Masjedizadeh, Mohammad R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High specific activity tritium labeling of vitamin D derivative RO275646</atitle><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle><addtitle>J Label Compd Radiopharm</addtitle><date>2005-12</date><risdate>2005</risdate><volume>48</volume><issue>14</issue><spage>1013</spage><epage>1023</epage><pages>1013-1023</pages><issn>0362-4803</issn><eissn>1099-1344</eissn><abstract>The octahydroindenone intermediate was tritium labeled using T2O isotope exchange labeling, and then elaborated to the vitamin D derivative RO275646. Though this method of labeling was expected to give the minor isomer, it was the shortest and most convenient route to the high specific activity metabolically stable labeled sites. A total of 34 mCi (from two separate runs) at 64 Ci/mmol of [3H]‐RO275646 were prepared by this method. Copyright © 2005 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/jlcr.1014</doi><tpages>11</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0362-4803 |
ispartof | Journal of labelled compounds & radiopharmaceuticals, 2005-12, Vol.48 (14), p.1013-1023 |
issn | 0362-4803 1099-1344 |
language | eng |
recordid | cdi_crossref_primary_10_1002_jlcr_1014 |
source | Wiley-Blackwell Read & Publish Collection |
subjects | Biological and medical sciences Contrast media. Radiopharmaceuticals exchange labeling Medical sciences minor isomer Pharmacology. Drug treatments T2O tritium vitamin D |
title | High specific activity tritium labeling of vitamin D derivative RO275646 |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T07%3A06%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-istex_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=High%20specific%20activity%20tritium%20labeling%20of%20vitamin%20D%20derivative%20RO275646&rft.jtitle=Journal%20of%20labelled%20compounds%20&%20radiopharmaceuticals&rft.au=de%20Keczer,%20Steve%20A.&rft.date=2005-12&rft.volume=48&rft.issue=14&rft.spage=1013&rft.epage=1023&rft.pages=1013-1023&rft.issn=0362-4803&rft.eissn=1099-1344&rft_id=info:doi/10.1002/jlcr.1014&rft_dat=%3Cistex_cross%3Eark_67375_WNG_6RBNMX9B_S%3C/istex_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c2524-486f618fd303e6b6780dd5c7d490016da8dfc9307b710c5a8155a6ea44a65c143%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |