An efficient laboratory synthesis of α-deuteriated profens

An efficient and practical laboratory synthesis of a series of 2‐deuterio‐2‐arylpropionic acids (α‐deuterioprofens) is described. The levels of deuterium incorporation are high and the products are synthetically useful. Copyright © 2006 John Wiley & Sons, Ltd.

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Bibliographic Details
Published in:Journal of labelled compounds & radiopharmaceuticals 2006-09, Vol.49 (10), p.903-914
Main Authors: Coumbarides, Gregory S., Dingjan, Marco, Eames, Jason, Flinn, Anthony, Northen, Julian
Format: Article
Language:English
Subjects:
2-phenyl-propionic acid and profens
Biological and medical sciences
carboxylic acids
Contrast media. Radiopharmaceuticals
deuterium
Medical sciences
Pharmacology. Drug treatments
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Description
Summary:An efficient and practical laboratory synthesis of a series of 2‐deuterio‐2‐arylpropionic acids (α‐deuterioprofens) is described. The levels of deuterium incorporation are high and the products are synthetically useful. Copyright © 2006 John Wiley & Sons, Ltd.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.1105