Preparation of tritium-labeled Silybin-a protectant for common liver diseases

Silymarin, the seed extract of milk thistle plant, Silybum marianum, has been used traditionally for the treatment of liver diseases and bile duct infection. Silybin 1 is the main bioactive components of silymarin, consisting a pair of diastereomers: Silybin A and Silybin B. In this article, we repo...

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Bibliographic Details
Published in:Journal of labelled compounds & radiopharmaceuticals 2006-10, Vol.49 (12), p.1125-1130
Main Authors: Lee, D. Y. W., Zhang, X., Ji, X. S.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Contrast media. Radiopharmaceuticals
Medical sciences
Pharmacology. Drug treatments
silymarin
synthesis of tritium labeled Silybin
tritiation
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Summary:Silymarin, the seed extract of milk thistle plant, Silybum marianum, has been used traditionally for the treatment of liver diseases and bile duct infection. Silybin 1 is the main bioactive components of silymarin, consisting a pair of diastereomers: Silybin A and Silybin B. In this article, we report the preparation of tritium‐labeled Silybin, which was accomplished by protection of Silybin as tritylated compound 2 and followed by oxidation of the primary alcohol to its corresponding aldehyde 3. Subsequent reduction with NaB[3H]4 and deprotection of the trityl group provided the tritium‐labeled Silybin 4. Copyright © 2006 John Wiley & Sons, Ltd.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.1132