Synthesis of a carbon-11 labelled agonist of the α7 nicotinic acetylcholine receptors

The lead compound of a new series of azabicyclic carbamates, described by Astra Laboratories, namely Astra‐255082 (N‐(4‐bromophenyl)carbamic acid quinuclidin‐3‐yl ester) has been labelled with carbon‐11 using no‐carrier‐added [11C]phosgene.

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Bibliographic Details
Published in:Journal of labelled compounds & radiopharmaceuticals 2001-05, Vol.44 (S1), p.S7-S8
Main Authors: Dollé, F., Hinnen, F., Valette, H., Demphel, S., Coulon, C., Ottaviani, M., Bottlaender, M., Crouzel, C.
Format: Article
Language:English
Subjects:
[11C]Astra-255082
Carbon-11
α7 nAChR
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Description
Summary:The lead compound of a new series of azabicyclic carbamates, described by Astra Laboratories, namely Astra‐255082 (N‐(4‐bromophenyl)carbamic acid quinuclidin‐3‐yl ester) has been labelled with carbon‐11 using no‐carrier‐added [11C]phosgene.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.2580440103