Synthesis and characterization of [99mTc]metomidate as the tricarbonyl-conjugate

Functionalized metomidate was labelled with the [99mTc]tricarbonyl‐complex in high yield. With carrier amounts of Tc‐99 the analogous [99Tc]tricarbonyl‐BiPy‐MTO‐conjugate was obtained, showing an identical retention time, however, conjugate formation was not quantitative. When the [Re]tribromo‐trica...

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Bibliographic Details
Published in:Journal of labelled compounds & radiopharmaceuticals 2001-05, Vol.44 (S1), p.S624-S626
Main Authors: Netter, M., Zolle, I., Schibli, R., Hammerschmidt, F., Berger, M., Schubiger, P. A.
Format: Article
Language:English
Subjects:
Conjugation of metomidate
Tricarbonyl-technetium
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Summary:Functionalized metomidate was labelled with the [99mTc]tricarbonyl‐complex in high yield. With carrier amounts of Tc‐99 the analogous [99Tc]tricarbonyl‐BiPy‐MTO‐conjugate was obtained, showing an identical retention time, however, conjugate formation was not quantitative. When the [Re]tribromo‐tricarbonyl‐ligand was reacted with the BiPy‐MTO‐precursor, the reaction parameters had to be optimized for conjugate formation. Based on high adrenocortical binding to adrenal tissue slices, it is expected that the radiotracer will also localize in the adrenal in‐vivo.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.25804401221