Preparation of 213 bi‐dota‐biotin in high specific activity for pretargeted alpha radiotherapy of cancer

The alpha emitter, Bismuth‐213, ( 213 Bi) T 1/2 = 45 min, obtained from an 225 Ac generator, was chelated to DOTA‐biotin in high radiochemical yield and specific activity. The radiolabeled product showed good radiochemical stability and was used in preclinical therapy studies using a pretargeting fo...

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Bibliographic Details
Published in:Journal of labelled compounds & radiopharmaceuticals 2001-05, Vol.44 (S1)
Main Authors: Hylarides, Mark D., Axworthy, Don B., Fritzberg, Alan R.
Format: Article
Language:English
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Summary:The alpha emitter, Bismuth‐213, ( 213 Bi) T 1/2 = 45 min, obtained from an 225 Ac generator, was chelated to DOTA‐biotin in high radiochemical yield and specific activity. The radiolabeled product showed good radiochemical stability and was used in preclinical therapy studies using a pretargeting format.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.25804401256