Design and evaluation of an external high‐current target for production of 211 At

• Published in: Journal of labelled compounds & radiopharmaceuticals 2012-10, Vol.55 (12), p.436-440
• Main Authors: Gagnon, K., Risler, R., Pal, S., Hamlin, D., Orzechowski, J., Pavan, R., Zeisler, S., Wilbur, D. S.
• Format: Article
• Language: English
• ISSN: 0362-4803; 1099-1344
• DOI: 10.1002/jlcr.2968

This report presents the design and testing of an external target system for clinical‐scale production of 211 At on the Scanditronix MC‐50 cyclotron at the University of Washington Medical Center. While other 211 At production sites have typically employed an internal target, an external target setup was deemed necessary at our facility since the cyclotron's main application is for cancer patient treatment via fast neutron therapy. The challenge was that previous external 211 At targets demonstrated reduced yields when compared to internal target systems. The target developed in this study has been used in more than 100 irradiations. From those irradiations 211 At saturated yields of 181 ± 16 MBq/μA and 241 ± 17 MBq/μA at 28.0 and 29.0 MeV, respectively, were obtained. Importantly, consistent yields were observed over the 25–60 μA range of irradiation currents evaluated. With a recent production in excess of 4 GBq 211 At for a 29.0 MeV, 58 μA, 4‐hour irradiation, this external target system has demonstrated its potential for producing clinically relevant quantities of 211 At.