Synthesis of tritium labeled isotopomers of L-tyrosine

The synthesis of four selectively labeled isotopomers of L‐tyrosine, (L‐Tyr), using chemical and enzymatic methods is reported. Four tritium labeled isotopomers of L‐phenylalanine (L‐Phe) – [2‐3H]‐, [2′,6′‐3H2]‐, [3R‐3H]‐ and [3S‐3H]‐ have been synthesized using a combination of chemical and enzymat...

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Bibliographic Details
Published in:Journal of labelled compounds & radiopharmaceuticals 2002-06, Vol.45 (7), p.559-567
Main Authors: Augustyniak, W., Suchecki, P., Jemielity, J., Kański, R., Kańska, M.
Format: Article
Language:English
Subjects:
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
enzyme
Fundamental and applied biological sciences. Psychology
labeling
Methods. Procedures. Technologies
optical isotopomer
phenylalanine
tritium
tyrosine
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Summary:The synthesis of four selectively labeled isotopomers of L‐tyrosine, (L‐Tyr), using chemical and enzymatic methods is reported. Four tritium labeled isotopomers of L‐phenylalanine (L‐Phe) – [2‐3H]‐, [2′,6′‐3H2]‐, [3R‐3H]‐ and [3S‐3H]‐ have been synthesized using a combination of chemical and enzymatic methods. The labeled isotopomers of L‐Phe have been converted into [2 ‐3H]‐, [2′,6′‐3H2]‐, [3R‐3H]‐, and [3S‐3H]‐L‐Tyr by using the enzyme L‐phenyl‐alanine 4′‐monooxygenase. Copyright © 2002 John Wiley & Sons, Ltd.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.582