The synthesis and characterisation of deuteriated amides

Results are reported on the regioselective C‐deuteriation of a series of enolates derived from the addition of sec‐BuLi to a variety of substituted amides. The outcomes of the reactions are discussed in terms of the structural nature of the amides and the deuteriated sources employed. Copyright © 20...

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Bibliographic Details
Published in:Journal of labelled compounds & radiopharmaceuticals 2003-10, Vol.46 (11), p.1033-1053
Main Authors: Coumbarides, Gregory S., Eames, Jason, Ghilagaber, Stephanos
Format: Article
Language:English
Subjects:
Chemistry
D-amides and isotopic labels
deprotonation-deuteriation
deuterium donor
Exact sciences and technology
kinetic deuteriation
Organic chemistry
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Summary:Results are reported on the regioselective C‐deuteriation of a series of enolates derived from the addition of sec‐BuLi to a variety of substituted amides. The outcomes of the reactions are discussed in terms of the structural nature of the amides and the deuteriated sources employed. Copyright © 2003 John Wiley & Sons, Ltd.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.737