Separation of isomeric disaccharides by traveling wave ion mobility mass spectrometry using CO 2 as drift gas

The use of CO 2 as a massive and polarizable drift gas is shown to greatly improve peak‐to‐peak resolution ( R p‐p ), as compared with N 2 , for the separation of disaccharides in a Synapt G2 traveling wave ion mobility cell. Near or baseline R p‐p was achieved for three pairs of sodiated molecules...

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Bibliographic Details
Published in:Journal of mass spectrometry. 2012-12, Vol.47 (12), p.1643-1647
Main Authors: Fasciotti, Maíra, Sanvido, Gustavo B., Santos, Vanessa G., Lalli, Priscila M., McCullagh, Michael, de Sá, Gilberto F., Daroda, Romeu J., Peter, Martin G., Eberlin, Marcos N.
Format: Article
Language:English
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Summary:The use of CO 2 as a massive and polarizable drift gas is shown to greatly improve peak‐to‐peak resolution ( R p‐p ), as compared with N 2 , for the separation of disaccharides in a Synapt G2 traveling wave ion mobility cell. Near or baseline R p‐p was achieved for three pairs of sodiated molecules of disaccharide isomers, that is, cellobiose and sucrose ( R p‐p  = 0.76), maltose and sucrose ( R p‐p  = 1.04), and maltose and lactose ( R p‐p  = 0.74). Ion mobility mass spectrometry using CO 2 as the drift gas offers therefore an attractive alternative for fast and efficient separation of isomeric disaccharides. Copyright © 2012 John Wiley & Sons, Ltd.
ISSN:1076-5174
1096-9888
DOI:10.1002/jms.3089