Studies of Preservatives of Poliomyelitis (Salk) Vaccine I

Several antimicrobial materials may be present in killed Salk poliomyelitis vaccine. They are (a) antibiotics which are added to the tissue culture to inhibit growth of bacterial contaminants without inhibiting growth of the poliomyelitis virus, (b) formaldehyde added to kill the virus, and (c) pres...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1963-09, Vol.52 (9), p.883-888
Main Authors: pivnick, Hilliard, Tracy, J.M., Glass, D.G.
Format: Article
Language:English
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Summary:Several antimicrobial materials may be present in killed Salk poliomyelitis vaccine. They are (a) antibiotics which are added to the tissue culture to inhibit growth of bacterial contaminants without inhibiting growth of the poliomyelitis virus, (b) formaldehyde added to kill the virus, and (c) preservatives such as benzethonium chloride added to the finished vaccine to prevent the growth of bacterial and fungal contaminants. The stable antibiotics contribute considerable antibacterial activity; the formaldehyde, if not neutralized by bisulfite, is an effective, stable antibacterial agent with some antifungal activity. Benzethonium chloride adds little, if any, antibacterial activity to that obtained either by antibiotics or formaldehyde but does furnish some antifungal activity.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600520915