Comparative Study in Man and Dog of the Absorption and Excretion of Dextroamphetamine-14 C Sulfate in Sustained-Release and Nonsustained-Release Dosage Forms

The absorption and excretion of dextroamphetarnine-14C sulfate in both sustained-release and nonsustained-release dosage forms were evaluated in identical studies in man and dog. A direct comparison of the results of these studies showed that the various dosage forms performed in a similar way in bo...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1967-03, Vol.56 (3), p.365-369
Main Authors: Rosen, Earl, Ellison, Theodore, Tannenbaum, Philip, Crosley, Archer P., Free, Spencer M.
Format: Article
Language:English
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Summary:The absorption and excretion of dextroamphetarnine-14C sulfate in both sustained-release and nonsustained-release dosage forms were evaluated in identical studies in man and dog. A direct comparison of the results of these studies showed that the various dosage forms performed in a similar way in both man and dog. These results provided information on the design and evaluation of in vivo studies intended to indicate which preliminary sustained-release formulations merit objective human testing.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600560312