Correlation Between the Rate of Dissolution and Absorption of Salicylarnide from Tablet and Suspension Dosage Forms

The in vivo absorption and the in vitro dissolution characteristics of a commercial suspension, a commercial tablet, and an experimental tablet formulation of the analgesic-antipyretic drug salicylamide were compared. The results of the study demonstrated that the absorption of this drug is dissolut...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1969-12, Vol.58 (12), p.1468-1470
Main Authors: Bates, Theodore R., Lambert, Daniel A., Johns, William H.
Format: Article
Language:English
Subjects:
Absorption rates-salicylamide dosage forms
Colorimetric analysis-spectrophotometer
correlation
Dissolution rates-salicylamide dosage forms
Salicylamide dosage forms-absorption-dissolution rates
Salicylamide dosage forms—absorption-dissolution rates, correlation
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Summary:The in vivo absorption and the in vitro dissolution characteristics of a commercial suspension, a commercial tablet, and an experimental tablet formulation of the analgesic-antipyretic drug salicylamide were compared. The results of the study demonstrated that the absorption of this drug is dissolution rate-dependent and that the initial in vitro dissolution rate in 0.1 N HCl correlates well with the initial absorption rates of the test dosage forms in human subjects.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600581209