Heterogeneous Systems II: Influence of Partitioning and Molecular Interactions on in vitro BiologicActivity of Preservatives in Emulsions

The preservative activity of p-hydroxybenzoic acid esters (parabens) in the presence of a polysorbate 80-sorbitan monooleate water system was found to be related to the concentration of the free or unbound paraben. Prediction of required preservative concentration for an emulsified system from a kno...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1970-03, Vol.59 (3), p.372-376
Main Authors: Patel, Nagin K., Romanowski, Joyce M.
Format: Article
Language:English
Subjects:
Biological activity—emulsion preservatives in vitro
Emulsions, effect—preservatives
Inhibition determination—dialysis cell
p-Hydroxybenzoic acid esters activity—partitioning, molecular interaction, effects
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Summary:The preservative activity of p-hydroxybenzoic acid esters (parabens) in the presence of a polysorbate 80-sorbitan monooleate water system was found to be related to the concentration of the free or unbound paraben. Prediction of required preservative concentration for an emulsified system from a knowledge of oil–water partition coefficients and preservative-macromolecules binding data is illustrated. It was demonstrated by an in vitro microbiological procedure and using a glass dialysis cell that the fungistatic activity against Aspergillus niger of methyl- and propylparaben in emulsified systems was primarily a function of the free paraben concentration in the aqueous phase.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600590321