Serum Levels of Chloramphenicol in Children,Rhesus Monkeys, and Cats after Administration ofChloramphenicol Palmitate Suspension

• Published in: Journal of pharmaceutical sciences 1971-01, Vol.60 (1), p.153-155
• Main Authors: Banerjee, Sachchidananda, Bandyopadhyay, Asok, Bhattacharjee, Ramesh Chandra, Mukherjee, Arun Kumar, Halder, Arup Kumar
• Format: Article
• Language: English
• Subjects: Chloramphenicol serum levels—following chloramphenicol palmitate suspension administration, in children, rhesus monkeys, cats; Polysorbate 80—effects on absorption of chloramphenicol palmitate (amorphous and polymorph A forms), in cats; Serum levels, chloramphenicol, amorphous versus polymorph A forms—comparison in children, rhesus monkeys, cats
• ISSN: 0022-3549; 1520-6017
• DOI: 10.1002/jps.2600600139

The absorption of amorphous and polymorph A forms of chloramphenicol palmitate suspensions made with polysorbate 80 was investigated in children, rhesus monkeys, and cats. In children, both forms were absorbed. While polymorph A was absorbed at a slower rate, maintaining the blood level of chloramphenicol for 6 hr., the amorphous form was absorbed maximally at 2 hr. followed by a profound fall in the blood level. Although the absorption of the amorphous form was definitely superior, the polymorph A form in suspension with a surface-active agent was also absorbed to a considerable extent in children, maintaining blood levels of chloramphenicol for a prolonged period. In experiments with cats, polysorbate 80 increased the absorption of both forms of chloramphenicol palmitate, with the amorphous variety having superior absorption. In rhesus monkeys, there was little absorption of the polymorph A form of chloramphenicol palmitate in suspension, possibly indicating the absorption as species specific.