Coulometric Titration of N-Isopropyl-α-(2-methylhydrazino)-p-toluamide Hydrochloride

A coulometric titration for the determination of N-isopropyl-α-(2-methylhydrazino)-p-toluamide hydrochloride, procarbazine hydrochloride, is described. The method is specific and is based on the quantitative oxidation of procarbazine hydrochloride by internally generated iodine to the corresponding...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1971-12, Vol.60 (12), p.1851-1853
Main Authors: Oliveri-Vigh, S., Donahue, J.J., Heveran, J.E., Senkowski, B.Z.
Format: Article
Language:English
Subjects:
coulometric titration
Coulometry-analysis
Coulometry—analysis, procarbazine hydrochloride
Iodine-oxidation of procarbazine hydrochloride
Iodine—oxidation of procarbazine hydrochloride, coulometric titration
N-Isopropyl-α-(2-methylhydrazino)-p-toluamide hydrochloride-analysis
N-Isopropyl-α-(2-methylhydrazino)-p-toluamide hydrochloride—analysis, coulometric titration
procarbazine hydrochloride
Procarbazine hydrochloride-analysis
Procarbazine hydrochloride—analysis, coulometric titration
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Summary:A coulometric titration for the determination of N-isopropyl-α-(2-methylhydrazino)-p-toluamide hydrochloride, procarbazine hydrochloride, is described. The method is specific and is based on the quantitative oxidation of procarbazine hydrochloride by internally generated iodine to the corresponding “azo” compound. The standard deviation for the method was ±0.2 and ±0.3%, while the precision ts at the 95% confidence level was ±0.6 and ±0.7% for the drug substance and capsules, respectively.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600601218