Vehicle and Route of Administration as Parameters Mecting Operant Behavioral Effects of ∆9-Tetrahydrocannabinol

Four vehicles for Δ9-tetrahydrocannabinol were compared after intraperitoneal and subcutaneous administrations, using the disruption of food-reinforced, operant behavior of rats as the test system for cannabinoid activity. Aqueous suspensions based on polyvinylpyrrolidone, polysorbate 80, and a poly...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1973-03, Vol.62 (3), p.479-480
Main Authors: Borgen, Lowell A., Davis, W. Marvin
Format: Article
Language:English
Subjects:
Cannabinoid activity—studied by operant behavioral effects in rats, different vehicles and routes of administration
Marijuana—effect of vehicle and route of administration of Δ9-tetrahydrocannabinol on operant behavior, rats
Δ9-Tetrahydrocannabinol—effect of vehicle and route of administration on operant behavior, rats
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Summary:Four vehicles for Δ9-tetrahydrocannabinol were compared after intraperitoneal and subcutaneous administrations, using the disruption of food-reinforced, operant behavior of rats as the test system for cannabinoid activity. Aqueous suspensions based on polyvinylpyrrolidone, polysorbate 80, and a polysorbate 65-sorbitan monolaurate combination all were effective vehicles for intraperitoneal or subcutaneous absorption of the cannabinoid. An olive oil solution was poorly effective. The polyvinylpyrrolidone dispersion appeared to have the most rapid onset of action, while the polysorbate 65-sorbitan monolaurate combination had the longest duration of action.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600620327