Synthesis and Antimalarial Activity of Heterocyclic Alkyl Disulfides, Thiosulfates, and Dithio Acid Derivatives

Based on the antimalarial activity in mice of bis(4‐p‐acetamidobenzenesulfonamidophenyl) disulfide, a series of N‐heterocyclic alkyl disulfides and thiosulfates was synthesized and screened for antimalarial activity. Several related dithio acid dianions and S‐blocked derivatives were also screened t...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pharmaceutical sciences 1975-02, Vol.64 (2), p.211-216
Main Authors: Foye, William O., Lanzillo, Joseph J., Lowe, Young Hee, Kauffman, Joel M.
Format: Article
Language:English
Subjects:
and dithio acid derivatives-synthesis and antimalarial activity
Animals
Antimalarial agents
Antimalarial agents, potential‐synthesis, screening of heterocyclic alkyl disulfides, thiosulfates, dithio acid derivatives
Antimalarials - chemical synthesis
Antimalarials - therapeutic use
Chickens
Disulfides
Disulfides - chemical synthesis
Disulfides - therapeutic use
Disulfides, heterocyclic alkyl‐synthesis and antimalarial activity
dithio acid derivatives
Dithio acid derivatives-synthesis and antimalarial activity
Female
Guinea Pigs
Heterocyclic alkyl disulfides
Heterocyclic alkyl disulfides, thiosulfates, and dithio acid derivatives‐synthesis and antimalarial activity
heterocyclic alkyl-synthesis and antimalarial activity
Malaria - drug therapy
Oxidation-Reduction
Plasmodium berghei
potential-synthesis
screening of heterocyclic alkyl disulfides
Sulfhydryl Compounds - chemical synthesis
Sulfhydryl Compounds - therapeutic use
thiosulfates
Thiosulfates - chemical synthesis
Thiosulfates - therapeutic use
Thiosulfates, heterocyclic alkyl‐synthesis and antimalarial activity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Based on the antimalarial activity in mice of bis(4‐p‐acetamidobenzenesulfonamidophenyl) disulfide, a series of N‐heterocyclic alkyl disulfides and thiosulfates was synthesized and screened for antimalarial activity. Several related dithio acid dianions and S‐blocked derivatives were also screened to provide an indication of the possible role that thiol anions might play in malaria chemotherapy. Activity was limited by toxicity with these compounds, and none of those tested, with the exception of bis(4‐p‐acetamidobenzenesulfonamidophenyl) disulfide, showed curative activity in either a mouse or chick test.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600640204