Comparison of protective effects of ethylestrenol, norbolethone, and spironolactone against lethality from acute doses of parathion and paraoxon in female rats

Protection against the toxicity of parathion (increased LD50) was provided by preadministered ethylestrenol and, to a lesser extent, by norbolethone and spironolactone. Ethylestrenol and norbolethone also offered protection against paraoxon toxicity. With ethylestrenol and spironolactone, the protec...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1976-04, Vol.65 (4), p.595-596
Main Authors: Robinson, Casey P., Smith, Paul W., McConnell, Judy K., Endecott, Boyd R.
Format: Article
Language:English
Subjects:
and spironolactone
Animals
compared to ethylestrenol and norbolethone
compared to ethylestrenol and spironolactone
compared to norbolethone and spironolactone
effect of ethylestrenol
Ethylestrenol - pharmacology
Ethylestrenol-effect on toxicity of parathion and paraoxon
Ethylestrenol—effect on toxicity of parathion and paraoxon, compared to norbolethone and spironolactone, rats
Female
Lethal Dose 50
norbolethone
Norbolethone-effect on toxicity of parathion and paraoxon
Norbolethone—effect on toxicity of parathion and paraoxon, compared to ethylestrenol and spironolactone, rats
Norpregnenes - pharmacology
Paraoxon - antagonists & inhibitors
Paraoxon - toxicity
Paraoxon-toxicity in rats
Paraoxon—toxicity in rats, effect of ethylestrenol, norbolethone, and spironolactone
Parathion - antagonists & inhibitors
Parathion - toxicity
Parathion-toxicity in rats
Parathion—toxicity in rats, effect of ethylestrenol, norbolethone, and spironolactone
Rats
Spironolactone - pharmacology
Spironolactone-effect on toxicity of parathion and paraoxon
Spironolactone—effect on toxicity of parathion and paraoxon, compared to ethylestrenol and norbolethone, rats
Time Factors
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Description
Summary:Protection against the toxicity of parathion (increased LD50) was provided by preadministered ethylestrenol and, to a lesser extent, by norbolethone and spironolactone. Ethylestrenol and norbolethone also offered protection against paraoxon toxicity. With ethylestrenol and spironolactone, the protection against parathion lethality was greater than that against paraoxon lethality.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600650429