Influence of Human Skin Surface Lipids on Protection Time of Topical Mosquito Repellent

Skin surface lipids were extracted from volunteers who had been ranked according to the duration of protection from mosquitoes by diethyltoluamide. These lipids were analyzed by GLC-mass spectrometry for their fatty acid contents. Correlations were found between total skin lipid content and protecti...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1977-12, Vol.66 (12), p.1764-1766
Main Authors: Skinner, W.A., Tong, H.C., Johnson, H., Parkhurst, R.M., Thomas, D., Spencer, T., Akers, W., Skidmore, D., Maibach, H.
Format: Article
Language:English
Subjects:
Administration, Topical
Aedes
Chromatography, Gas
Diethyltoluamide-protection time
Diethyltoluamide—protection time, effect of skin surface lipids, humans
effect of skin surface lipids
humans
Insect Repellents - administration & dosage
insect-diethyltoluamide
Lipids
Lipids - analysis
Lipids - physiology
Lipids, skin surface—effect on protection time of diethyltoluamide, humans
Mass Spectrometry
protection time
Regression Analysis
Repellents
Repellents, insect—diethyltoluamide, protection time, effect of skin surface lipids, humans
Skin - analysis
Skin Physiological Phenomena
skin surface-effect on protection time of diethyltoluamide
Time Factors
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Description
Summary:Skin surface lipids were extracted from volunteers who had been ranked according to the duration of protection from mosquitoes by diethyltoluamide. These lipids were analyzed by GLC-mass spectrometry for their fatty acid contents. Correlations were found between total skin lipid content and protection time of diethyltoluamide and between certain fatty acid concentrations in the skin lipids and the protection time of diethyltoluamide.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600661229