Identification of Senecionine and Senecionine N-Oxide as Antifertility Constituents in Senecio vulgaris

The MeOH extract of Senecio vulgaris L., administered po to rats on Days 1–10 postcoitum, significantly decreased the number of normal fetuses per pregnant rat found at autopsy on Day 16. Additional experiments showed a similar activity for its hepatotoxic constituents senecionine and senecionine N-...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1988-05, Vol.77 (5), p.461-463
Main Authors: Tu, Zhi-Ben, Konno, Chohachi, Soejarto, D. Doel, Waller, Donald P., Bingel, Audrey S., Molyneux, Russell J., Edgar, John A., Cordell, Geoffrey A., Fong, Harry H.S.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Contraceptive Agents - analysis
Cricetinae
Female
General pharmacology
Male
Medical sciences
Mesocricetus
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Toxic
Pregnancy
Pyrrolizidine Alkaloids - analysis
Pyrrolizidine Alkaloids - isolation & purification
Pyrrolizidine Alkaloids - pharmacology
Rats
Rats, Inbred Strains
Senecio - analysis
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Summary:The MeOH extract of Senecio vulgaris L., administered po to rats on Days 1–10 postcoitum, significantly decreased the number of normal fetuses per pregnant rat found at autopsy on Day 16. Additional experiments showed a similar activity for its hepatotoxic constituents senecionine and senecionine N-oxide, suggesting that the latter two compounds were probably responsible for the effect seen with the extract. No antifertility effects were seen in MeOH extract-treated hamsters.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600770522