Determination of the Antimalarial Arteether and its Deethylated Metabolite Dihydroartemisinin in Plasma by High-Performance Liquid Chromatography with Reductive Electrochemical Detection

A rapid, sensitive, and specific reversed-phase HPLC method using reductive electrochemical detection has been developed for the determination of arteether and its O-dealkylated metabolite dihydroartemisinin (DQHS) in plasma. The internal standard assay was validated between 25 and 1000 ng/mL, with...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1991-02, Vol.80 (2), p.132-138
Main Authors: Melendez, Victor, Peggins, James O., Brewer, Thomas G., Theoharides, Anthony D.
Format: Article
Language:English
Subjects:
Analysis
Animals
Antimalarials - blood
Antimalarials - pharmacokinetics
Artemisinins
Biological and medical sciences
Biological Availability
Chromatography, High Pressure Liquid - methods
Dogs
Electrochemistry - methods
General pharmacology
Medical sciences
Oxidation-Reduction
Pharmacology. Drug treatments
Reproducibility of Results
Sesquiterpenes - blood
Sesquiterpenes - pharmacokinetics
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Description
Summary:A rapid, sensitive, and specific reversed-phase HPLC method using reductive electrochemical detection has been developed for the determination of arteether and its O-dealkylated metabolite dihydroartemisinin (DQHS) in plasma. The internal standard assay was validated between 25 and 1000 ng/mL, with a coefficient of variation of
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600800209