Population Characteristics of Cyclodextrin Complex Stabilities in Aqueous Solution

Binding constants (K11) of 1:1 complexes of α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin with many substrates (guests) were collected from published sources and subjected to statistical analysis. All systems refer to 25 ± 5°C and aqueous solution. The frequency distributions of logK11are satis...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1995-07, Vol.84 (7), p.843-848
Main Author: Connors, Kenneth A.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cyclodextrins - chemistry
Cyclodextrins - metabolism
Drug Stability
General pharmacology
Kinetics
Mathematics
Medical sciences
Nitrophenols - chemistry
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Time Factors
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Summary:Binding constants (K11) of 1:1 complexes of α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin with many substrates (guests) were collected from published sources and subjected to statistical analysis. All systems refer to 25 ± 5°C and aqueous solution. The frequency distributions of logK11are satisfactorily described by normal distributions with the following parameters (n= number of complexes, μ = population mean, σ = population standard deviation): α-cyclodextrin,n= 663, μ = 2.11, σ = 0.90; β-cyclodextrin,n= 721, μ = 2.69, σ = 0.89; γ-cyclodextrin,n= 166, μ = 2.55, σ = 0.93. Stabilities of pairs of cyclodextrin complexes with a common substrate are not precisely correlated, but they do not appear to be wholly independent quantities. The stabilities of α-cyclodextrin complexes are consistent with a recent interpretation of solvent effects on α-cyclodextrin complex stabilities.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600840712