Prognostic role of SOX2 and STAT3 expression on circulating T lymphocytes and CD44+/CD24 neg cells in the locally advanced and metastatic breast cancer

Breast cancer (BC) is associated with a continuous increase in incidence, with high mortality rates in several countries. CD44, STAT3, and SOX2 are related to regulating of somatic cell division, tumorigenesis, and metastasis in BC. A cross-sectional study was carried out at the Hospital de Cancer d...

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Bibliographic Details
Published in:Journal of surgical oncology 2024-09, Vol.130 (4), p.669-680
Main Authors: Sobral, Denise V, Salgado, Marcelo R T, Martins, Mario R, Vasconcelos, Carolina de S, Anunciação, Carlos E C, de Andrade, Victor P, Torres, Leuridan C
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers, Tumor - blood
Biomarkers, Tumor - metabolism
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
CD24 Antigen - metabolism
Cross-Sectional Studies
Female
Follow-Up Studies
Humans
Hyaluronan Receptors - metabolism
Middle Aged
Prognosis
SOXB1 Transcription Factors - metabolism
STAT3 Transcription Factor - metabolism
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
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Summary:Breast cancer (BC) is associated with a continuous increase in incidence, with high mortality rates in several countries. CD44, STAT3, and SOX2 are related to regulating of somatic cell division, tumorigenesis, and metastasis in BC. A cross-sectional study was carried out at the Hospital de Cancer de Pernambuco (HCP) between 2017 and 2018. Fifty-one women with locally advanced (LA) and 14 with metastatic BC were included in the study. High CD44+/CD24 and CD44+/CD24 /SOX2+ levels in Luminal B (LB), HER2+, and triple-negative breast cancer (TNBC) compared with controls (p 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.27716